Moclobemide effects on prolactin plasma levels in healthy individuals: the hormonal increase induced by a single dose is maintained during a 4-week period of drug intake

Moclobemide effects on prolactin plasma levels in healthy individuals: the hormonal increase induced by a single dose is maintained during a 4-week period of drug intake

Autor Juruena, M. F. Google Scholar
Pires, MLN Google Scholar
Calil, H. M. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Neuroendocrine challenge studies are frequently used to study the pathophysiology of psychiatric illnesses and the effects of psychotropic drug treatment on brain monoamine function. Moclobemide, a reversible inhibitor of monoamine oxidase, with predominant effects on the A-type of the enzyme, was administered to 15 healthy men. Seven out of the 15 also received single blind placebo a week before the moclobemide. the individuals received moclobemide as a single dose (150 mg), followed by doses of 150 mg three times a day, during a 4-week period. Plasma prolactin was measured in the morning over a 150-min period, following the single dose, and then at the end of weeks 1, 2 and 4 of moclobemide intake. the present data show an acute and transitory increase of plasma prolactin levels after the single dose, and also during the long-term moclobemide administration. It might indicate that steady-state moclobemide levels, during the long-term drug administration, were low and thus large fluctuations of drug levels occurred between doses. Thus, it is suggested that larger doses or administering smaller doses more frequently, or both, may induce hyperprolactinaemia with clinical consequences.
Palavra-chave healthy individuals
moclobemide
monoamines
monoamine oxidase type A inhibitor
prolactin
Idioma Inglês
Data de publicação 1997-11-01
Publicado em International Clinical Psychopharmacology. Philadelphia: Lippincott Williams & Wilkins, v. 12, n. 6, p. 317-321, 1997.
ISSN 0268-1315 (Sherpa/Romeo, fator de impacto)
Publicador Lippincott Williams & Wilkins
Extensão 317-321
Fonte http://dx.doi.org/10.1097/00004850-199711000-00004
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000071359000004
Endereço permanente http://repositorio.unifesp.br/handle/11600/25808

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