Effects of age on a new animal model of tardive dyskinesia

Effects of age on a new animal model of tardive dyskinesia

Autor Bergamo, M. Google Scholar
Abilio, V. C. Google Scholar
Queiroz, CMT Google Scholar
Barbosa, H. N. Google Scholar
Abdanur, LRA Google Scholar
Frussa, R. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The effects of age were studied on a new animal model of tardive dyskinesia, i.e., the quantification of oral dyskinesia in rats repeatedly treated with reserpine. Adult and old rats received two injections of reserpine (0.5 or 1.0 mg/kg s.c.) or vehicle, separated by 48 h. One, 10, 25 and 40 days after the second injection of reserpine or vehicle, the animals were observed for quantification of the behavioral parameters of oral dyskinesia: tongue protrusion and vacuous chewing movement frequencies and duration of twitching of the facial musculature. Phenomenologically, control old rats and reserpine-treated adult animals showed very similar oral dyskinesia. When compared to control adult rats, the significant increase in tongue protrusion frequency induced by reserpine treatment was more persistent in the old rats than in the adult animals. Because it is well known that age increases the persistence of tardive dyskinesia, our data provide further support for the validation of reserpine-induced oral dyskinesia as an animal model of tardive dyskinesia. in addition, the possibility is raised that a common pathophysiological mechanism may underlie tardive dyskinesia and age- and reserpine-induced oral dyskinesia. (C) 1997 Elsevier Science Inc.
Palavra-chave oral dyskinesia
reserpine
rats
senility
Idioma Inglês
Data de publicação 1997-11-01
Publicado em Neurobiology of Aging. New York: Elsevier B.V., v. 18, n. 6, p. 623-629, 1997.
ISSN 0197-4580 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 623-629
Fonte http://dx.doi.org/10.1016/S0197-4580(97)00152-8
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000071494700007
Endereço permanente http://repositorio.unifesp.br/handle/11600/25806

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