Absence of oxidative stress following paradoxical sleep deprivation in rats

Absence of oxidative stress following paradoxical sleep deprivation in rats

Autor DAlmeida, V Google Scholar
Hipolide, D. C. Google Scholar
Azzalis, L. A. Google Scholar
Lobo, L. L. Google Scholar
Junqueira, VBC Google Scholar
Tufik, S. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Resumo Paradoxical sleep deprivation was performed on rats using platform technique to investigate the oxidative process associated with it. Levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), total glutathione (GSH) and malondialdehyde production were measured in brain of rats under control conditions (C) and those on single large platforms (SLP), multiple large platforms (MLP), single small platforms (SSP) and multiple small platforms (MSP) groups. SOD, CAT and GPx brain activity and malondialdehyde production were not modified by any of the procedures. Brain GSH, however, was significantly reduced in both SSP and SLP groups. These results suggest that paradoxical sleep deprivation per se is not associated with oxidative damage. the observed alterations could be attributed to factors such as immobilization and social isolation present in the single platform techniques. (C) 1997 Elsevier Science Ireland Ltd.
Palavra-chave paradoxical sleep deprivation
oxidative stress
glutathione
antioxidant defense
lipid peroxidation
Idioma Inglês
Data de publicação 1997-10-10
Publicado em Neuroscience Letters. Clare: Elsevier Sci Ireland Ltd, v. 235, n. 1-2, p. 25-28, 1997.
ISSN 0304-3940 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 25-28
Fonte http://dx.doi.org/10.1016/S0304-3940(97)00706-4
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1997YE13300007
Endereço permanente http://repositorio.unifesp.br/handle/11600/25798

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