Maternal immunization to Gov system alloantigens on human platelets

Maternal immunization to Gov system alloantigens on human platelets

Autor Bordin, J. O. Google Scholar
Kelton, J. G. Google Scholar
Warner, M. N. Google Scholar
Smith, J. W. Google Scholar
Denomme, G. A. Google Scholar
Warkentin, T. E. Google Scholar
McGrath, K. Google Scholar
Minchinton, R. Google Scholar
Hayward, CPM Google Scholar
Universidade Federal de São Paulo (UNIFESP)
Resumo BACKGROUND: Immunization to platelet alloantigens can occur during pregnancy or after the transfusion of blood components. Platelet alloantibodies can cause neonatal alloimmune thrombocytopenia and posttransfusion purpura. Transfusion-induced alloimmunization to a novel platelet alloantigen system, Gov, expressed on the 175-kDa glycosyl phosphatidylinositol-anchored platelet glycoprotein, CD109, was previously described. This report describes three unrelated patients who were alloimmunized to Gov(a) or Gov(b) during pregnancy.STUDY DESIGN and METHODS: Platelets were typed by using radioimmunoprecipitation for HPA-1a, -3a, -5a, -5b, Gov(a), and GoV(b) and by polymerase chain reaction-restriction fragment length polymorphism for HPA-la, -1b, -3a, and -3b. Maternal sera were screened for platelet antibodies by using radioimmunoprecipitation and the antigen capture assay. RESULTS: Patients 1 and 2 were investigated after the diagnosis of neonatal alloimmune thrombocytopenia in their children, and alloantibodies specific for Gov(b) and Gov(a), respectively were detected in maternal serum. Serum from patient 3, who had mild idiopathic thrombocytopenia purpura with no detectable autoantibody, was found to contain alloantibodies to Gov(b) and to HPA-5b, presumably as a result of immunization during pregnancy. Platelet typings confirmed that the patients were at risk for alloimmunization to the respective antigen.CONCLUSION:This report of three cases of maternal alloimmunization to antigens in the Gov system indicates that immunization can occur via placental transfer of antigen and that Gov system alloantibodies may be associated with neonatal alloimmune thrombocytopenia.
Idioma Inglês
Data 1997-08-01
Publicado em Transfusion. Bethesda: Amer Assoc Blood Banks, v. 37, n. 8, p. 823-828, 1997.
ISSN 0041-1132 (Sherpa/Romeo, fator de impacto)
Editor Amer Assoc Blood Banks
Extensão 823-828
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1997XT16500009

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