Hormonal and metabolic adaptations to fasting in monosodium glutamate obese rats

Hormonal and metabolic adaptations to fasting in monosodium glutamate obese rats

Autor Ribeiro, E. B. Google Scholar
doNascimento, CMO Google Scholar
Andrade, I. S. Google Scholar
Hirata, A. E. Google Scholar
Dolnikoff, M. S. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The effect of fasting on hormonal and metabolic variables was evaluated in normal rats and in rats with obesity induced by neonatal treatment with monosodium glutamate (MSG). the hyperinsulinemia of the fed obese rats was reversed by fasting. Plasma corticosterone was also high in the fed obese and decreased to levels similar to fed controls, while it increased in the latter group during fasting. in contrast, thyroid hormone levels decreased in controls but increased in the obese rats in response to fasting. the fed obese group had lower carcass protein and higher carcass lipid contents than controls. in response to fasting, the decrements of the initial amount of both protein and fat were lower in MSG than in controls. Fasting induced a sustained increase in plasma free fatty acids only in the obese rats, although a single 100 mu mol.l(-1) dose of norepinephrine stimulated in vitro glycerol release more pronouncedly in epididymal adipocytes from control than obese rats. the results indicate that MSG-obese rats were able to mobilize fat stores during prolonged fasting. the high availability of lipid fuels and the sharp and sustained decrease in circulating corticosterone in the MSG group were probably important in diminishing body protein consumption during fasting.
Palavra-chave starvation
obesity
corticosterone
thyroid hormones
body protein
body fat
Idioma Inglês
Data de publicação 1997-08-01
Publicado em Journal of Comparative Physiology B-biochemical Systemic and Environmental Physiology. New York: Springer Verlag, v. 167, n. 6, p. 430-437, 1997.
ISSN 0174-1578 (Sherpa/Romeo, fator de impacto)
Publicador Springer
Extensão 430-437
Fonte http://dx.doi.org/10.1007/s003600050093
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1997XR02500005
Endereço permanente http://repositorio.unifesp.br/handle/11600/25768

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