Neuropeptide-Y immunoreactivity in the pilocarpine model of temporal lobe epilepsy

Show simple item record Lurton, D. Cavalheiro, E. A. 2016-01-24T12:30:24Z 2016-01-24T12:30:24Z 1997-08-01
dc.identifier.citation Experimental Brain Research. New York: Springer Verlag, v. 116, n. 1, p. 186-190, 1997.
dc.identifier.issn 0014-4819
dc.description.abstract Neuropeptide-Y (NPY) is expressed by granule cells and messy fibres of the hippocampal dentate gyrus during experimental temporal lobe epilepsy (TLE). This expression may represent an endogenous damping mechanism since NPY has been shown to block seizure-like events following high-frequency stimulation in hippocampal slices. the pilocarpine (PILO) model of epilepsy is characterized by an acute period of status epilepticus followed by spontaneous recurrent seizures and related brain damage. We report peroxidase-antiperoxidase immunostaining for NPY in several brain regions in this model. PILO-injected animals exhibited NPY immunoreactivity in the region of the messy fibre terminals, in the dentate gyrus inner molecular layer and, in a few cases, within presumed granule cells. NPY immunoreactivity was also dramatically changed in the entorhinal cortex, amygdala and sensorimotor areas. in addition, PILO injected animals exhibited a reduction in the number of NPY-immunoreactive interneurons compared with controls. the results demonstrate that changes in NPY expression, including expression in the granule cells and messy fibres and the loss of vulnerable NPY neurons, are present in the PILO model of TLE. However, the significance of this changed synthesis of NPY remains to be determined. en
dc.format.extent 186-190
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof Experimental Brain Research
dc.rights Acesso restrito
dc.subject pilocarpine en
dc.subject NPY en
dc.subject hippocampus en
dc.subject epilepsy en
dc.subject immunohistochemistry en
dc.subject rat en
dc.title Neuropeptide-Y immunoreactivity in the pilocarpine model of temporal lobe epilepsy en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation UNIFESP,ESCOLA PAULISTA MED,São Paulo,BRAZIL
dc.description.affiliationUnifesp UNIFESP,ESCOLA PAULISTA MED,São Paulo,BRAZIL
dc.identifier.doi 10.1007/PL00005739
dc.description.source Web of Science
dc.identifier.wos WOS:A1997XT50300021


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