Neuropeptide-Y immunoreactivity in the pilocarpine model of temporal lobe epilepsy

Neuropeptide-Y immunoreactivity in the pilocarpine model of temporal lobe epilepsy

Author Lurton, D. Google Scholar
Cavalheiro, E. A. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Neuropeptide-Y (NPY) is expressed by granule cells and messy fibres of the hippocampal dentate gyrus during experimental temporal lobe epilepsy (TLE). This expression may represent an endogenous damping mechanism since NPY has been shown to block seizure-like events following high-frequency stimulation in hippocampal slices. the pilocarpine (PILO) model of epilepsy is characterized by an acute period of status epilepticus followed by spontaneous recurrent seizures and related brain damage. We report peroxidase-antiperoxidase immunostaining for NPY in several brain regions in this model. PILO-injected animals exhibited NPY immunoreactivity in the region of the messy fibre terminals, in the dentate gyrus inner molecular layer and, in a few cases, within presumed granule cells. NPY immunoreactivity was also dramatically changed in the entorhinal cortex, amygdala and sensorimotor areas. in addition, PILO injected animals exhibited a reduction in the number of NPY-immunoreactive interneurons compared with controls. the results demonstrate that changes in NPY expression, including expression in the granule cells and messy fibres and the loss of vulnerable NPY neurons, are present in the PILO model of TLE. However, the significance of this changed synthesis of NPY remains to be determined.
Keywords pilocarpine
Language English
Date 1997-08-01
Published in Experimental Brain Research. New York: Springer Verlag, v. 116, n. 1, p. 186-190, 1997.
ISSN 0014-4819 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 186-190
Access rights Closed access
Type Article
Web of Science ID WOS:A1997XT50300021

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