Neuropeptide-Y immunoreactivity in the pilocarpine model of temporal lobe epilepsy

Neuropeptide-Y immunoreactivity in the pilocarpine model of temporal lobe epilepsy

Autor Lurton, D. Google Scholar
Cavalheiro, E. A. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Neuropeptide-Y (NPY) is expressed by granule cells and messy fibres of the hippocampal dentate gyrus during experimental temporal lobe epilepsy (TLE). This expression may represent an endogenous damping mechanism since NPY has been shown to block seizure-like events following high-frequency stimulation in hippocampal slices. the pilocarpine (PILO) model of epilepsy is characterized by an acute period of status epilepticus followed by spontaneous recurrent seizures and related brain damage. We report peroxidase-antiperoxidase immunostaining for NPY in several brain regions in this model. PILO-injected animals exhibited NPY immunoreactivity in the region of the messy fibre terminals, in the dentate gyrus inner molecular layer and, in a few cases, within presumed granule cells. NPY immunoreactivity was also dramatically changed in the entorhinal cortex, amygdala and sensorimotor areas. in addition, PILO injected animals exhibited a reduction in the number of NPY-immunoreactive interneurons compared with controls. the results demonstrate that changes in NPY expression, including expression in the granule cells and messy fibres and the loss of vulnerable NPY neurons, are present in the PILO model of TLE. However, the significance of this changed synthesis of NPY remains to be determined.
Palavra-chave pilocarpine
NPY
hippocampus
epilepsy
immunohistochemistry
rat
Idioma Inglês
Data de publicação 1997-08-01
Publicado em Experimental Brain Research. New York: Springer Verlag, v. 116, n. 1, p. 186-190, 1997.
ISSN 0014-4819 (Sherpa/Romeo, fator de impacto)
Publicador Springer
Extensão 186-190
Fonte http://dx.doi.org/10.1007/PL00005739
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1997XT50300021
Endereço permanente http://repositorio.unifesp.br/handle/11600/25767

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