Effect of low-dose oral and intravenous dexamethasone administration on growth hormone secretion in children

Effect of low-dose oral and intravenous dexamethasone administration on growth hormone secretion in children

Autor Pinto, ACAR Google Scholar
Weffort, RFVB Google Scholar
DiNinno, F. B. Google Scholar
Lengyel, AMJ Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Acute dexamethasone administration (2 mg/m(2) i.v. and 4 mg orally) increases growth hormone (CH) release in children. Wie evaluated the effect of a low intravenous dose (1 mg/m(2)) of dexamethasone on GH secretion in 8 short normal children and in 6 GH-deficient children. There was a significant GH increase at 120, 150 and 180 min in short normal children (maximal value: 18.9 +/- 2.1 mu g/l; (X) over bar + EP), compared to placebo administration. in contrast, no significant GH elevation was seen in GH-deficient children (1.3 +/- 0.4 mu g/l). There was no difference in the GH response after intravenous dexamethasone and oral clonidine in these same 8 short normal children and 6 GH-deficient children. Although no significant GH release was observed after dexamethasone or clonidine in GH deficiency, an increase in GH after GH-releasing hormone was seen (6.1 +/- 1.9 mu g/l). There was a significant GH increase (18.5 +/- 3.3 mu g/l) after low-dose (2-mg) oral dexamethasone administration in another 8 short normal children, which was similar to values after intravenous injection. No side effects were noted after intravenous or oral dexamethasone. in conclusion, low-dose intravenous or oral dexamethasone administration causes a marked GH release in short normal children, probably mediated by hypothalamic structures.
Assunto dexamethasone
growth hormone
children
Idioma Inglês
Data 1997-07-01
Publicado em Hormone Research. Basel: Karger, v. 48, n. 1, p. 5-10, 1997.
ISSN 0301-0163 (Sherpa/Romeo, fator de impacto)
Editor Karger
Extensão 5-10
Fonte http://dx.doi.org/10.1159/000185356
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1997XD68500002
URI http://repositorio.unifesp.br/handle/11600/25762

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