Morphologic and morphometric aspects of the endometrium of postmenopausal women before and after cyclic oestrogen replacement treatment

Morphologic and morphometric aspects of the endometrium of postmenopausal women before and after cyclic oestrogen replacement treatment

Autor Gomes, AMN Google Scholar
Baracat, E. C. Google Scholar
Simoes, M. J. Google Scholar
Haidar, Mauro Abi Autor UNIFESP Google Scholar
Focchi, GRA Google Scholar
EvencioNeto, J. Google Scholar
deLima, G. R. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Objective: the aim of the study is to observe the morphology and morphometry of the endometrium of postmenopausal women treated with cyclic conjugated oestrogens. Study design: Three groups of nine postmenopausal women received cyclic conjugated oestrogens for 21 days (with a seven-day pause) during six months. the endometrial specimens were obtained using a modified Novak suction curet, in the second or third day of the period of drug washout. the slides were stained with haematoxylin and eosin (H.E.) in order to measure epithelial height and determine the gland/stroma ratio. Results: Morphologic examination showed that single daily doses of 0.3 mg of conjugated oestrogens caused discrete endometrial proliferation after three and six months of treatment. However, a more intense effect was observed in women receiving doses of 0.625 and 1.25 mg/day of the hormone, in the same period. Morphometric study revealed significant increases both in epithelial thickness and in the gland-stroma ratio, specially in women receiving higher doses of the conjugated oestrogen (0.625 and 1.25 mg/day). Conclusions: We concluded that there were marked proliferative alterations without atypias in the endometrium of women that received 0.625 and 1.25 mg of conjugated oestrogens during six months. (C) 1997 Elsevier Science Ireland Ltd.
Palavra-chave postmenopausal endometrium
histomorphometry
oestrogen replacement treatment
Idioma Inglês
Data de publicação 1997-07-01
Publicado em European Journal of Obstetrics Gynecology and Reproductive Biology. Clare: Elsevier Sci Ireland Ltd, v. 74, n. 1, p. 79-82, 1997.
ISSN 0301-2115 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 79-82
Fonte http://dx.doi.org/10.1016/S0301-2115(97)00077-8
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1997XK22700018
Endereço permanente http://repositorio.unifesp.br/handle/11600/25757

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