Strategies used by hippocampal- and caudate-putamen-lesioned rats in a learning task

Strategies used by hippocampal- and caudate-putamen-lesioned rats in a learning task

Autor Oliveira, MGM Google Scholar
Bueno, OFA Google Scholar
Pomarico, A. C. Google Scholar
Gugliano, E. B. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo In rats, hippocampal lesions result in impairment of spatial navigation, although other learning abilities remain unaltered. When learning a left/right discrimination task, rats can use a spatial strategy (with external maze landmarks-Situation 1) or are forced to use an egocentric strategy (without external or internal maze cues-Situation 2). Little is known about the extrahippocampal systems involved in the utilization of egocentric strategy. It is suggested that striatum could play an important role in the learning abilities that are spared after hippocampal lesion. the aim of our study was to investigate which strategy is used by rats bearing hippocampal or caudate-putamen lesions in the acquisition of a left/right discrimination task in an elevated T-maze in both Situations 1 and 2. We also investigated the effect of each lesion on the reversal of discrimination in both situations. Acquisition was not altered in any of the situations; however, a transfer test showed that hippocampal-lesioned rats used a different strategy (egocentric) from control animals (spatial) in Situation 1. in addition, reversal of the discrimination was impaired in Situation 2. Caudate-putamen lesion produced a transient effect on reversal of discrimination only in the egocentric task (Situation 2), but did not impair acquisition of the task in either situation, thus suggesting that the animals were able to use either strategy. (C) 1997 Academic Press.
Idioma Inglês
Data de publicação 1997-07-01
Publicado em Neurobiology of Learning and Memory. San Diego: Academic Press Inc Jnl-comp Subscriptions, v. 68, n. 1, p. 32-41, 1997.
ISSN 1074-7427 (Sherpa/Romeo, fator de impacto)
Publicador Academic Press Inc Jnl-comp Subscriptions
Extensão 32-41
Fonte http://dx.doi.org/10.1006/nlme.1996.3761
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1997XE32500004
Endereço permanente http://repositorio.unifesp.br/handle/11600/25753

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