Fibronectin in the ascitic fluid of cirrhotic patients: correlation with biochemical risk factors for the development of spontaneous bacterial peritonitis

Fibronectin in the ascitic fluid of cirrhotic patients: correlation with biochemical risk factors for the development of spontaneous bacterial peritonitis

Autor Mesquita, Regina Celia Aguiar Autor UNIFESP Google Scholar
Leite-Mór, Marilisa Moraes Barros Autor UNIFESP Google Scholar
Parise, Edison Roberto Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Cirrhotic patients (23 with alcoholic cirrhosis, 5 with posthepatitic cirrhosis and 2 with cryptogenic cirrhosis) with ascites and portal hypertension were studied and divided into two groups corresponding to high or low risk to develop spontaneous bacterial peritonitis (SEP) related to the concentration of total protein in the ascitic fluid (A-TP): group I (high risk): A-TP less than or equal to 1.5 g/dl and group II(low risk): A-TP>1.5 g/dl. Fibronectin (FN), C3 and C4 concentrations were measured by radial immunodiffusion while total protein was measured by the biuret method. the mean values (group I vs group II) of C3 (12.59 +/- 4.72 vs 24.53 +/- 15.58 mg/dl), C4 (4.26 +/- 3.87 vs 7.26 +/- 4.14 mg/dl) and FN (50.47 +/- 12.49 vs 75.89 +/- 24.70 mg/dl) in the ascitic fluid were significantly lower (P<0.05) in the group considered to be at high risk for SEP. No significant difference was observed in the plasma/ascites fibronectin ratio (3.91 +/- 1.21 vs 3.80 +/- 1.26) or gradient (131.46 +/- 64.01 vs 196.96 +/- 57.38) between groups. Fibronectin in ascites was significantly correlated to C3 (r = 0.76), C4 (r = 0.58), total protein (r = 0.73) and plasma FN (r = 0.58) (P<0.05). the data suggest that the FN concentration in ascites is related to the opsonic capacity of this fluid, and that its concentration in the ascitic fluid may be a biochemical risk factor indicator for the development of spontaneous bacterial peritonitis.
Palavra-chave fibronectin
spontaneous bacterial
peritonitis
ascites
Idioma Inglês
Data de publicação 1997-07-01
Publicado em Brazilian Journal of Medical and Biological Research. São Paulo: Assoc Bras Divulg Cientifica, v. 30, n. 7, p. 843-847, 1997.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Publicador Assoc Bras Divulg Cientifica
Extensão 843-847
Fonte http://dx.doi.org/10.1590/S0100-879X1997000700004
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:A1997XN66100004
SciELO S0100-879X1997000700004 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/25750

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