Effects of buspirone on dopaminergic supersensitivity

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dc.contributor.author Queiroz, CMT
dc.contributor.author Frussa, R.
dc.date.accessioned 2016-01-24T12:30:22Z
dc.date.available 2016-01-24T12:30:22Z
dc.date.issued 1997-06-20
dc.identifier http://dx.doi.org/10.1016/S0024-3205(97)00394-9
dc.identifier.citation Life Sciences. Oxford: Pergamon-Elsevier B.V., v. 61, n. 4, p. 371-382, 1997.
dc.identifier.issn 0024-3205
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/25744
dc.description.abstract The effects of buspirone treatment on dopaminergic supersensitivity induced by long-term haloperidol administration were studied; both spontaneous activity (locomotion and rearing frequencies) of rats observed in an open-field and apomorphine-induced stereotypy were used as experimental parameters. Buspirone per se (3.0 mg/kg, twice daily, for 30 days) did not produce dopaminergic supersensitivity. When buspirone was given in combination to haloperidol (2.0 mg/kg, once daily, for 30 days), it decreased the neuroleptic withdrawal symptoms as detected in open-field behavior but not in apomorphine-induced stereotypy. Although single administration of buspirone per se decreased both open-field and apomorphine-induced stereotypy behavior, buspirone single administration did not modify the acute effects of haloperidol on these two behavioral models. Taken together with previous behavioral results showing that buspirone reverses haloperidol-induced catalepsy, the present data suggest that buspirone coadministration may lead to important clinical advantages concerning different extrapyramidal side effects of neuroleptic treatment. en
dc.format.extent 371-382
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Life Sciences
dc.rights Acesso restrito
dc.subject haloperidol en
dc.subject buspirone en
dc.subject dopaminergic supersensitivity en
dc.subject open-field stereotypy en
dc.subject stereotypy en
dc.title Effects of buspirone on dopaminergic supersensitivity en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo,ESCOLA PAULISTA MED,DEPT FARMACOL,BR-04023062 São Paulo,BRAZIL
dc.description.affiliationUnifesp Universidade Federal de São Paulo,ESCOLA PAULISTA MED,DEPT FARMACOL,BR-04023062 São Paulo,BRAZIL
dc.identifier.doi 10.1016/S0024-3205(97)00394-9
dc.description.source Web of Science
dc.identifier.wos WOS:A1997XG97100004



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