Effects of buspirone on dopaminergic supersensitivity

Effects of buspirone on dopaminergic supersensitivity

Autor Queiroz, CMT Google Scholar
Frussa, R. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The effects of buspirone treatment on dopaminergic supersensitivity induced by long-term haloperidol administration were studied; both spontaneous activity (locomotion and rearing frequencies) of rats observed in an open-field and apomorphine-induced stereotypy were used as experimental parameters. Buspirone per se (3.0 mg/kg, twice daily, for 30 days) did not produce dopaminergic supersensitivity. When buspirone was given in combination to haloperidol (2.0 mg/kg, once daily, for 30 days), it decreased the neuroleptic withdrawal symptoms as detected in open-field behavior but not in apomorphine-induced stereotypy. Although single administration of buspirone per se decreased both open-field and apomorphine-induced stereotypy behavior, buspirone single administration did not modify the acute effects of haloperidol on these two behavioral models. Taken together with previous behavioral results showing that buspirone reverses haloperidol-induced catalepsy, the present data suggest that buspirone coadministration may lead to important clinical advantages concerning different extrapyramidal side effects of neuroleptic treatment.
Palavra-chave haloperidol
buspirone
dopaminergic supersensitivity
open-field stereotypy
stereotypy
Idioma Inglês
Data de publicação 1997-06-20
Publicado em Life Sciences. Oxford: Pergamon-Elsevier B.V., v. 61, n. 4, p. 371-382, 1997.
ISSN 0024-3205 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 371-382
Fonte http://dx.doi.org/10.1016/S0024-3205(97)00394-9
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1997XG97100004
Endereço permanente http://repositorio.unifesp.br/handle/11600/25744

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