Evaluation of the in vitro activity of cefepime compared to other broad-spectrum cephalosporins against clinical isolates from eighteen Brazilian hospitals by using the Etest

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dc.contributor.author Sader, H. S.
dc.contributor.author Mimica, I
dc.contributor.author Rossi, F.
dc.contributor.author Zoccoli, C.
dc.contributor.author Montelli, A. C.
dc.contributor.author Sampaio, JLM
dc.contributor.author Segura, AJA
dc.contributor.author Magalhaes, M.
dc.contributor.author Nowakonski, A.
dc.contributor.author Mendes, CMF
dc.date.accessioned 2016-01-24T12:30:21Z
dc.date.available 2016-01-24T12:30:21Z
dc.date.issued 1997-06-01
dc.identifier http://dx.doi.org/10.1016/S0732-8893(97)00015-1
dc.identifier.citation Diagnostic Microbiology and Infectious Disease. New York: Elsevier B.V., v. 28, n. 2, p. 87-92, 1997.
dc.identifier.issn 0732-8893
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/25735
dc.description.abstract The in vitro activity of cefepime was compared to that of ceftazidime, ceftriaxone, and cefotaxime in a multicenter study involving 10 clinical microbiology laboratories and clinical isolates from 18 Brazilian hospitals from 7 cities (4 states). A total of 982 isolates consecutively collected between December 1995 and March 1996 were susceptibility tested by using Etest and following the NCCLS procedures for agar diffusion tests. the cefepime spectrum was broader than that of the other broad-spectrum cephalosporins against both Gram-negative rods and Gram-positive cocci. Cefepime tons particularly move active against Enterobacter sp. (MIC90, 2 mu g/ml), Serratia sp. (MIC90, 2 mu g/ml) and oxacillin-susceptible Staphylococcus aureus (MIC90, 3 mu g/ml). Against Pseudomonas aeruginosa, cefepime (MIC90 16 mu g/ml) was slightly more active than ceftazidime (MIC90 32 mu g/ml) and 8- to 16-fold more active than ceftriaxone or cefotaxime (MIC90 >256 mu g/ml). Our results show that nosocomial bacteria, especially Gram-negative rods, have a high rate of cephalosporin resistance in Brazil. However, part of these resistant bacteria remains susceptible to cefepime. the Etest was shown to be an excellent method for multicenter studies of the in vitro evaluation of new antimicrobial agents. (C) 1997 Elsevier Science Inc. en
dc.format.extent 87-92
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Diagnostic Microbiology and Infectious Disease
dc.rights Acesso restrito
dc.title Evaluation of the in vitro activity of cefepime compared to other broad-spectrum cephalosporins against clinical isolates from eighteen Brazilian hospitals by using the Etest en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution SANTA CASA MISERICORDIA São Paulo
dc.contributor.institution EMILIO RIBAS HOSP
dc.contributor.institution SANTA LUZIA LAB
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution LAMINA LAB
dc.contributor.institution HOSP BASE BRASILIA
dc.contributor.institution MARCELO MAGALHAES LAB
dc.contributor.institution Universidade Estadual de Campinas (UNICAMP)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation SANTA CASA MISERICORDIA São Paulo,São Paulo,BRAZIL
dc.description.affiliation EMILIO RIBAS HOSP,São Paulo,BRAZIL
dc.description.affiliation SANTA LUZIA LAB,FLORIANOPOLIS,SC,BRAZIL
dc.description.affiliation UNIV ESTADUAL PAULISTA JULIO MESQUITA FILHO,FAC MED,BOTUCATU,SP,BRAZIL
dc.description.affiliation LAMINA LAB,RIO JANEIRO,BRAZIL
dc.description.affiliation HOSP BASE BRASILIA,FHDF,BRASILIA,DF,BRAZIL
dc.description.affiliation MARCELO MAGALHAES LAB,RECIFE,PE,BRAZIL
dc.description.affiliation UNICAMP,HOSP CLIN,CAMPINAS,SP,BRAZIL
dc.description.affiliation UNIV São Paulo,COLL MED,HC,FM,CMFM,São Paulo,BRAZIL
dc.identifier.doi 10.1016/S0732-8893(97)00015-1
dc.description.source Web of Science
dc.identifier.wos WOS:A1997XK92200007



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