Evaluation of the in vitro activity of cefepime compared to other broad-spectrum cephalosporins against clinical isolates from eighteen Brazilian hospitals by using the Etest

Evaluation of the in vitro activity of cefepime compared to other broad-spectrum cephalosporins against clinical isolates from eighteen Brazilian hospitals by using the Etest

Autor Sader, H. S. Google Scholar
Mimica, I Google Scholar
Rossi, F. Google Scholar
Zoccoli, C. Google Scholar
Montelli, A. C. Google Scholar
Sampaio, JLM Google Scholar
Segura, AJA Google Scholar
Magalhaes, M. Google Scholar
Nowakonski, A. Google Scholar
Mendes, CMF Google Scholar
Instituição SANTA CASA MISERICORDIA São Paulo
EMILIO RIBAS HOSP
SANTA LUZIA LAB
Universidade de São Paulo (USP)
LAMINA LAB
HOSP BASE BRASILIA
MARCELO MAGALHAES LAB
Universidade Estadual de Campinas (UNICAMP)
Universidade Federal de São Paulo (UNIFESP)
Resumo The in vitro activity of cefepime was compared to that of ceftazidime, ceftriaxone, and cefotaxime in a multicenter study involving 10 clinical microbiology laboratories and clinical isolates from 18 Brazilian hospitals from 7 cities (4 states). A total of 982 isolates consecutively collected between December 1995 and March 1996 were susceptibility tested by using Etest and following the NCCLS procedures for agar diffusion tests. the cefepime spectrum was broader than that of the other broad-spectrum cephalosporins against both Gram-negative rods and Gram-positive cocci. Cefepime tons particularly move active against Enterobacter sp. (MIC90, 2 mu g/ml), Serratia sp. (MIC90, 2 mu g/ml) and oxacillin-susceptible Staphylococcus aureus (MIC90, 3 mu g/ml). Against Pseudomonas aeruginosa, cefepime (MIC90 16 mu g/ml) was slightly more active than ceftazidime (MIC90 32 mu g/ml) and 8- to 16-fold more active than ceftriaxone or cefotaxime (MIC90 >256 mu g/ml). Our results show that nosocomial bacteria, especially Gram-negative rods, have a high rate of cephalosporin resistance in Brazil. However, part of these resistant bacteria remains susceptible to cefepime. the Etest was shown to be an excellent method for multicenter studies of the in vitro evaluation of new antimicrobial agents. (C) 1997 Elsevier Science Inc.
Idioma Inglês
Data de publicação 1997-06-01
Publicado em Diagnostic Microbiology and Infectious Disease. New York: Elsevier B.V., v. 28, n. 2, p. 87-92, 1997.
ISSN 0732-8893 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 87-92
Fonte http://dx.doi.org/10.1016/S0732-8893(97)00015-1
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1997XK92200007
Endereço permanente http://repositorio.unifesp.br/handle/11600/25735

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