Blockade of pilocarpine- or kainate-induced mossy fiber sprouting by cycloheximide does not prevent subsequent epileptogenesis in rats

Blockade of pilocarpine- or kainate-induced mossy fiber sprouting by cycloheximide does not prevent subsequent epileptogenesis in rats

Autor Longo, B. M. Google Scholar
Mello, LEAM Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Post-injury sprouting of hippocampal messy fibers has been suggested to be a causal mechanism underlying the development of temporal lobe epilepsy. However, this hypothesis rests entirely on indirect correlational evidence. Here we demonstrate that cycloheximide, a protein synthesis inhibitor, blocked pilocarpine- and kainate-induced messy fiber sprouting in rats, bur did not prevent the subsequent development of spontaneous seizures or affect their frequency. These results provide direct evidence against a causal role for messy fiber sprouting in temporal lobe epileptogenesis. (C) 1997 Elsevier Science Ireland Ltd.
Palavra-chave epilepsy
spontaneous seizures
hippocampus
pilocarpine
kainic acid
protein synthesis inhibitor
mossy fiber sprouting
Idioma Inglês
Data de publicação 1997-05-02
Publicado em Neuroscience Letters. Clare: Elsevier Sci Ireland Ltd, v. 226, n. 3, p. 163-166, 1997.
ISSN 0304-3940 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 163-166
Fonte http://dx.doi.org/10.1016/S0304-3940(97)00267-X
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1997WY62200006
Endereço permanente http://repositorio.unifesp.br/handle/11600/25725

Exibir registro completo




Arquivo

Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta