Allele frequency of ADH2 and ALDH2 among Brazilians of different ethnic groups

Allele frequency of ADH2 and ALDH2 among Brazilians of different ethnic groups

Author Santos, B. R. Google Scholar
Monteiro, M. G. Google Scholar
Thomasson, H. R. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Uberlândia (UFU)
INDIANA UNIV
Abstract We determined the genotypes of the alcohol dehydrogenase (ALDH) and aldehyde dehydrogenase (ALDH2) loci of different ethnic groups living in Brazil, using saliva DNA amplified by PCR and allele-specific oligonucleotides. Self-reports of flushing reaction after drinking were also studied. the allelic frequencies of ADH2 and ALDH2 were found to be lower than those reported other authors, which might be a result of the admixture origin of the Brazilian population. Variability in facial flushing reaction suggests that other factors play a role in the expression of alcohol-induced flushing. (C) 1997 Elsevier Science Inc.
Keywords alcohol dehydrogenase
aldehyde dehydrogenase
alcohol
ethanol metabolizing isoenzymes
ethnic differences
genetic polymorphism
alcohol flushing
Language English
Date 1997-05-01
Published in Alcohol. New York: Elsevier B.V., v. 14, n. 3, p. 205-207, 1997.
ISSN 0741-8329 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 205-207
Origin http://dx.doi.org/10.1016/S0741-8329(96)00066-3
Access rights Closed access
Type Article
Web of Science ID WOS:A1997WZ02500001
URI http://repositorio.unifesp.br/handle/11600/25720

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