Allele frequency of ADH2 and ALDH2 among Brazilians of different ethnic groups

Allele frequency of ADH2 and ALDH2 among Brazilians of different ethnic groups

Autor Santos, B. R. Google Scholar
Monteiro, M. G. Google Scholar
Thomasson, H. R. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Uberlândia (UFU)
INDIANA UNIV
Resumo We determined the genotypes of the alcohol dehydrogenase (ALDH) and aldehyde dehydrogenase (ALDH2) loci of different ethnic groups living in Brazil, using saliva DNA amplified by PCR and allele-specific oligonucleotides. Self-reports of flushing reaction after drinking were also studied. the allelic frequencies of ADH2 and ALDH2 were found to be lower than those reported other authors, which might be a result of the admixture origin of the Brazilian population. Variability in facial flushing reaction suggests that other factors play a role in the expression of alcohol-induced flushing. (C) 1997 Elsevier Science Inc.
Palavra-chave alcohol dehydrogenase
aldehyde dehydrogenase
alcohol
ethanol metabolizing isoenzymes
ethnic differences
genetic polymorphism
alcohol flushing
Idioma Inglês
Data de publicação 1997-05-01
Publicado em Alcohol. New York: Elsevier B.V., v. 14, n. 3, p. 205-207, 1997.
ISSN 0741-8329 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 205-207
Fonte http://dx.doi.org/10.1016/S0741-8329(96)00066-3
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1997WZ02500001
Endereço permanente http://repositorio.unifesp.br/handle/11600/25720

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