Schizophrenia and chromosome 6p

Schizophrenia and chromosome 6p

Autor Turecki, Gustavo Google Scholar
Rouleau, Guy A. Google Scholar
Joober, Ridha Google Scholar
Mari, Jair de Jesus Autor UNIFESP Google Scholar
Morgan, Kenneth Google Scholar
Instituição MCGILL UNIV
Universidade Federal de São Paulo (UNIFESP)
Resumo Several studies have recently reported genetic linkage between markers located on the short arm of chromosome 6 and schizophrenia, Valid conclusions, however, are difficult to formulate because chromosomal markers that yielded positive results span a relatively large region of chromosome 6, and studies did not necessarily obtain consistent results with regard to the particular loci tested, Here, we report a meta-analysis of the results of linkage studies of schizophrenia that used chromosome 6p markers. After conducting a systematic search, nine different studies mere selected for the analysis using defined criteria, Pooled P values were obtained for all common markers investigated and provided additional support for a major susceptibility locus for schizophrenia in this region. in addition, two markers located 2 cM apart, D6S274 and D6S285, provided the most significant results, These findings may help narrow the chromosomal region in the search for a major gene implicated in schizophrenia, (C) 1997 Wiley-Lies, Inc.
Palavra-chave psychiatric disorder
linkage analysis
meta-analysis
Idioma Inglês
Data de publicação 1997-04-18
Publicado em American Journal of Medical Genetics. New York: Wiley-liss, v. 74, n. 2, p. 195-198, 1997.
ISSN 0148-7299 (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 195-198
Fonte http://dx.doi.org/10.1002/(SICI)1096-8628(19970418)74:2<195
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:A1997WV79700016
Endereço permanente http://repositorio.unifesp.br/handle/11600/25715

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