Cardiorespiratory effects of L-glutamate microinjected into the rat ventral medulla

Cardiorespiratory effects of L-glutamate microinjected into the rat ventral medulla

Autor Tolentino-Silva, Fatima Rosaria Paulino Autor UNIFESP Google Scholar
Campos, R. R. Google Scholar
Russo, A. K. Google Scholar
Cravo, S. L. Google Scholar
Lopes, O. U. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo We investigated the cardiorespiratory effects elicited by microinjections of L-glutamate (L-glu, 25 nmol, 200 nl) at various sites in the ventral medulla (VMS) of urethane-anesthetized rats. the results demonstrated that regions responsive to the drug are located along a column in the VMS extending from the VI cranial nerve to the first cervical nerve in the caudal medulla. Within this column three breathing patterns were elicited from four distinct areas. in the most rostral and caudal portion of this hypothetical column, the breathing patterns observed in response to L-glu were similar and characterized by increases in minute ventilation, tidal volume, inspiratory drive, respiratory frequency, mean arterial blood pressure (MAP) and heart rate (HR). in the regions located between the areas described above two different breathing patterns were obtained without significant changes in MAP or HR. These patterns were characterized by decreases and increases in the respiratory indices analyzed, with the exception of respiratory frequency, which decreased in both regions. These results suggest that within the VMS discrete areas may act as functional units modulating cardiorespiratory responses while in others these functions are spatially segregated. (C) 1997 Elsevier Science B.V.
Palavra-chave ventral surface of the medulla
breathing pattern
cardiorespiratory control
L-glutamate
rat
Idioma Inglês
Data de publicação 1997-04-01
Publicado em Respiration Physiology. Amsterdam: Elsevier B.V., v. 108, n. 1, p. 23-33, 1997.
ISSN 0034-5687 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 23-33
Fonte http://dx.doi.org/10.1016/S0034-5687(97)02530-9
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1997XA56700003
Endereço permanente http://repositorio.unifesp.br/handle/11600/25711

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