Inhibition of gastric acid secretion by the aqueous extract and purified extracts of Stachytarpheta cayennensis

Inhibition of gastric acid secretion by the aqueous extract and purified extracts of Stachytarpheta cayennensis

Autor Mesia-Vela, Sonia Autor UNIFESP Google Scholar
Souccar, C. Google Scholar
LimaLandman, MTR Google Scholar
Lapa, A. J. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Stachytarpheta cayennensis Schauer (Verbenaceae) is used in folk medicine to treat gastric and intestinal disturbances. the freeze-dried aqueous extract of the whole plant tested to rodents up to the dose of 2 g kg(-1), p.o., did not produce signs of toxicity. the extract (0.5-2 g kg(-1), p.o.) increased the intestinal motility and protected mice against ulcers induced by restraint-in-cold, ethanol or indomethacin. Injected into the duodenal lumen the extract inhibited the basal acid secretion as well as that induced by histamine and bethanecol in pylorus-ligated mice. Partition of the aqueous extract in organic solvents yielded semipurified fractions whose antiacid activity guided further chemical purification. All the fractions were chromatographically characterized, the main substances in the active extract being flavonoids and amines; some substances were revealed only under UV light. the most purified active fraction obtained presented a specific activity 5-10 times higher than that detected in the original extract. Data from pharmacological studies indicate that the antiulcer activity of S. cayennensis is related to a specific inhibition of gastric acid secretion. Cholinergic and histaminergic stimulation of acid secretion were similarly reduced by the extracts suggesting inhibition of common steps in both pathways, possibly at the level of histamine release/H-2 receptor interaction, or at the proton pump. Whatever the mechanisms involved, the present data confirm the plant effectiveness as antiacid/antiulcer and laxative.
Assunto Stachytorpheta cayennensis
Idioma Inglês
Data 1997-02-01
Publicado em Planta Medica. Stuttgart: Georg Thieme Verlag, v. 63, n. 1, p. 36-39, 1997.
ISSN 0032-0943 (Sherpa/Romeo, fator de impacto)
Editor Georg Thieme Verlag
Extensão 36-39
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1997WN16800008

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