Pharmacological activity of Guarana (Paullinia cupana Mart) in laboratory animals

Pharmacological activity of Guarana (Paullinia cupana Mart) in laboratory animals

Autor Espinola, E. B. Google Scholar
Dias, R. F. Google Scholar
Mattei, R. Google Scholar
Carlini, E. A. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
UNIV FED PARAIBA
Resumo Mice that ingested a suspension of guarana (Paullinia cupana, Sapindaceae) in a dose of 0.3 mg/ml showed a significant increase in physical capacity when subjected to a stressful situation such as forced swimming after 100 and 200 days of treatment. Such an effect, however, was not obtained with a concentration of 3.0 mg/ml, nor with the ingestion of a suspension of ginseng 5.0 mg/ml, nor of a solution of caffeine 0.1 mg/ml. Guarana, both after a single (3.0 and 30 mg/kg) or chronic administrations (0.3 mg/ml), was able to partially reverse the amnesic effect of scopolamine as measured through a passive avoidance test in mice and rats, indicating a positive effect on memory acquisition. However, no effect was observed when an active avoidance task was used in rats, even after 20 days of guarana administration. There was also a tendency of rats treated with 0.3 mg/ml of guarana to better maintain the memory of a Lashley III maze path. the animals had the same average lifespan, indicating a low toxicity of guarana, even after 23 months of treatment. (C) 1997 Elsevier Science Ireland Ltd.
Palavra-chave Guarana
Paullinia cupana
memory
learning
physical capacity
Idioma Inglês
Data de publicação 1997-02-01
Publicado em Journal of Ethnopharmacology. Clare: Elsevier Sci Ireland Ltd, v. 55, n. 3, p. 223-229, 1997.
ISSN 0378-8741 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 223-229
Fonte http://dx.doi.org/10.1016/S0378-8741(96)01506-1
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1997WM91200008
Endereço permanente http://repositorio.unifesp.br/handle/11600/25689

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