Comparative efficacy of inhaled furosemide and disodium cromoglycate in the treatment of exercise-induced asthma in children

Comparative efficacy of inhaled furosemide and disodium cromoglycate in the treatment of exercise-induced asthma in children

Autor Melo, R. E. Google Scholar
Sole, D. Google Scholar
Naspitz, C. K. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Background: Inhaled furosemide has been shown, in patients with asthma, to have prophylactic properties similar to those of disodium cromoglycate.Objective: the aim of this study was to evaluate the protective effect of these drugs in the treatment of exercise-induced asthma.Methods: Fifteen children with exercise-induced asthma (mean age, 10.8 years) underwent exercise challenge after a single dose of nebulized placebo, furosemide (20 mg/m(2) body area), or disodium cromoglycate (20 mg), 2 days apart, in a single-blind crossover trial.Results: Both furosemide and disodium cromoglycate exerted significant protection against the bronchial response to exercise challenge, with a mean maximum percentage falls in FEV(1) of 4.66% and 7.22%, respectively (p < 0.05). On the placebo day, the mean maximum percentage fall in FEV(1) was 34.50% (p < 0.05).Conclusion: the results of this study suggest that furosemide and disodium cromoglycate provide comparable efficacy in preventing exercise-induce asthma in children, with no side effects.
Palavra-chave exercise-induced asthma
inhaled furosemide
disodium cromoglycate
children
Idioma Inglês
Data de publicação 1997-02-01
Publicado em Journal of Allergy and Clinical Immunology. St Louis: Mosby-year Book Inc, v. 99, n. 2, p. 204-209, 1997.
ISSN 0091-6749 (Sherpa/Romeo, fator de impacto)
Publicador Mosby-year Book Inc
Extensão 204-209
Fonte http://dx.doi.org/10.1016/S0091-6749(97)70097-6
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1997WH83100009
Endereço permanente http://repositorio.unifesp.br/handle/11600/25687

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