Repeated monosialoganglioside administration attenuates behavioral sensitization to amphetamine

Repeated monosialoganglioside administration attenuates behavioral sensitization to amphetamine

Autor Bellot, R. G. Google Scholar
Vital, MABF Google Scholar
PalermoNeto, J. Google Scholar
Frussa, R. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
UNIV FED PARANA
Universidade de São Paulo (USP)
Resumo The effects of repeated monosialoganglioside (GM1) administration on amphetamine-induced behavioral sensitization were studied using locomotion frequency of mice observed in an open-field as an experimental parameter. GM1 (30 mg/kg, once a day for 7 days) did not modify mouse behavior per se but decreased the hyperlocomotion of mice repeatedly treated with amphetamine (3.0 mg/kg, once a day for 7 days, 30 min after GM1 injection). GM1 acutely administered 30 min before amphetamine did not modify the increase in locomotion frequency induced by acute amphetamine administration. These results agree with previous reports that gangliosides treatment may affect synaptic plasticity, modifying the induction of the adaptive changes following drug treatment.
Palavra-chave monosialoganglioside
amphetamine
behavior
sensitization
locomotor activity
mice
Idioma Inglês
Data de publicação 1997-01-30
Publicado em Brain Research. Amsterdam: Elsevier B.V., v. 747, n. 1, p. 169-172, 1997.
ISSN 0006-8993 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 169-172
Fonte http://dx.doi.org/10.1016/S0006-8993(96)01256-5
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1997WG79800024
Endereço permanente http://repositorio.unifesp.br/handle/11600/25684

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