Isolation and sequence analysis of a human cDNA clone (XPNPEPL) homologous to X-prolyl aminopeptidase (aminopeptidase P)

Isolation and sequence analysis of a human cDNA clone (XPNPEPL) homologous to X-prolyl aminopeptidase (aminopeptidase P)

Autor Vanhoof, G. Google Scholar
Goossens, F. Google Scholar
Juliano, M. A. Google Scholar
Juliano, L. Google Scholar
Hendriks, D. Google Scholar
Schatteman, K. Google Scholar
Lin, A. H. Google Scholar
Scharpe, S. Google Scholar
Instituição Univ Instelling Antwerp
Universidade Federal de São Paulo (UNIFESP)
Resumo A novel human cDNA (XPNPEPL) encoding a protein of 623 amino acids exhibiting 44% sequence identity and 62% sequence similarity to pig kidney X-prolyl aminopeptidase (aminopeptidase P; EC 3.4.11.9) was obtained by reverse transcription/polymerase chain reaction of phytohemagglutinin-stimulated lymphocyte mRNA. Conserved sequences were found with the prokaryotic X-prolyl aminopeptidase encoding gene (pepP). the human gene translation product exhibits a high sequence homology to the Schizosaccharomyces pombe chromosome I hypothetical protein C22G7.01c and to the S. cerevisiae ORF y11029w. Northern blot analysis indicates an ubiquitous expression of the human XPNPEPL sequence.
Idioma Inglês
Data de publicação 1997-01-01
Publicado em Cytogenetics and Cell Genetics. Basel: Karger, v. 78, n. 3-4, p. 275-280, 1997.
ISSN 0301-0171 (Sherpa/Romeo, fator de impacto)
Publicador Karger
Extensão 275-280
Fonte http://dx.doi.org/10.1159/000134671
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000071902100026
Endereço permanente http://repositorio.unifesp.br/handle/11600/25678

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