Effect of chemical stimulation of the dorsomedial hypothalamic nucleus on blood plasma glucose, triglycerides and free fatty acids in rats

Effect of chemical stimulation of the dorsomedial hypothalamic nucleus on blood plasma glucose, triglycerides and free fatty acids in rats

Autor Zaia, CTBV Google Scholar
Gaziri, LCJ Google Scholar
Zaia, DAM Google Scholar
Delattre, E. Google Scholar
Dolnikoff, M. S. Google Scholar
TimoIaria, C. Google Scholar
Instituição Universidade Estadual de Londrina (UEL)
Universidade Estadual de Campinas (UNICAMP)
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Resumo The effects of chemical stimulation of the dorsomedial hypothalamic nucleus (DMH) on blood plasma concentration of glucose, triglycerides, insulin, and free fatty acids (FFA) were investigated in anesthetized adult Wistar rats. Microinjection of 12.5 nmol of norepinephrine into the DMH increased blood plasma concentration of glucose and FFA, decreased triglycerides, and did not change plasma insulin within 5 min; after 20 min, blood glucose and FFA reached control values. Microinjection of epinephrine (12.5 nmol) into the DMH also increased blood plasma glucose concentration and decreased triglycerides after 5 min. These effects are probably mediated by beta-adrenergic mechanisms, because they were prevented by beta-adrenergic antagonist propranolol, but not by alpha-adrenergic antagonist prazosin. Microinjection into the DMH of glutamate, dopamine, or acetylcholine failed to cause any change in those metabolic parameters, corroborating the hypothesis that the DMH is part of a beta-adrenergic pathway involved in short-term modulation of the availability of glucose and FFA. Copyright (C) 1997 Elsevier Science Inc.
Palavra-chave hypothalamus
hyperglycemia
adrenergic blockers
norepinephrine
epinephrine
Idioma Inglês
Data de publicação 1997-01-01
Publicado em Brain Research Bulletin. Oxford: Pergamon-Elsevier B.V., v. 42, n. 3, p. 195-198, 1997.
ISSN 0361-9230 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 195-198
Fonte http://dx.doi.org/10.1016/S0361-9230(96)00225-0
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1997WC70400004
Endereço permanente http://repositorio.unifesp.br/handle/11600/25658

Exibir registro completo




Arquivo

Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta