Effect of chemical stimulation of the dorsomedial hypothalamic nucleus on blood plasma glucose, triglycerides and free fatty acids in rats

Effect of chemical stimulation of the dorsomedial hypothalamic nucleus on blood plasma glucose, triglycerides and free fatty acids in rats

Author Zaia, CTBV Google Scholar
Gaziri, LCJ Google Scholar
Zaia, DAM Google Scholar
Delattre, E. Google Scholar
Dolnikoff, M. S. Google Scholar
TimoIaria, C. Google Scholar
Institution Universidade Estadual de Londrina (UEL)
Universidade Estadual de Campinas (UNICAMP)
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract The effects of chemical stimulation of the dorsomedial hypothalamic nucleus (DMH) on blood plasma concentration of glucose, triglycerides, insulin, and free fatty acids (FFA) were investigated in anesthetized adult Wistar rats. Microinjection of 12.5 nmol of norepinephrine into the DMH increased blood plasma concentration of glucose and FFA, decreased triglycerides, and did not change plasma insulin within 5 min; after 20 min, blood glucose and FFA reached control values. Microinjection of epinephrine (12.5 nmol) into the DMH also increased blood plasma glucose concentration and decreased triglycerides after 5 min. These effects are probably mediated by beta-adrenergic mechanisms, because they were prevented by beta-adrenergic antagonist propranolol, but not by alpha-adrenergic antagonist prazosin. Microinjection into the DMH of glutamate, dopamine, or acetylcholine failed to cause any change in those metabolic parameters, corroborating the hypothesis that the DMH is part of a beta-adrenergic pathway involved in short-term modulation of the availability of glucose and FFA. Copyright (C) 1997 Elsevier Science Inc.
Keywords hypothalamus
hyperglycemia
adrenergic blockers
norepinephrine
epinephrine
Language English
Date 1997-01-01
Published in Brain Research Bulletin. Oxford: Pergamon-Elsevier B.V., v. 42, n. 3, p. 195-198, 1997.
ISSN 0361-9230 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 195-198
Origin http://dx.doi.org/10.1016/S0361-9230(96)00225-0
Access rights Closed access
Type Article
Web of Science ID WOS:A1997WC70400004
URI http://repositorio.unifesp.br/handle/11600/25658

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