Osteopenia occurs in a minority of patients with acromegaly and is predominant in the spine

Osteopenia occurs in a minority of patients with acromegaly and is predominant in the spine

Autor Kayath, M. J. Google Scholar
Vieira, JGH Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Acromegaly may induce abnormalities in bone metabolism; however, there are limited data related to bone mineral density (BMT)) in this condition. To evaluate the effects of an excess of growth hormone/insulin-like growth fractor I(GH/IGF-I) in the skeleton, we measured the BMD in spine and femoral region, total body calcium and body composition in 45 patients (24 females and 21 males) aged 21-77 years (median 43 years) with acromegaly for 11.4 +/- 7.5 years (range 0.5-26 years) using a dual-energy X-ray absorptiometer (Lunar DPX). Thirty-four patients had had hypogonadism fur 8.6 +/- 6.5 years (1-24 years). Mean serum GH and IGF-I levels were respectively 159 +/- 183 mu g/l and 843 +/- 497 mu g/l. Total body calcium was increased in the acromegalics (males: 1272 +/- 217 g, range 916-1816 g; females: 1041 +/- 223 g,range 739-1609 g)when compared with normal individuals (males: 1115 +/- 144 g, range 856-1398 g; females: 909 +/- 144 g, range 511-1311 g; p = 0.01). the lean body mass was significantly higher in acromegalic patients (p<0.001) compared with normal individuals. There was a tendency for a lower fat percentage in the acromegalics; however, this difference was not significant. Osteopenia (I Z-score below the mean) was found in the spine in 20% (n = 9) of the patients, while BMD was decreased in the femoral region in only 8.8% (n = 4). the group with osteopenia had a greater duration of hypogonadism than the normal BMD group (14 +/- 11 years vs 4.4 +/- 4.0 years;p = 0.01). A negative correlation was also found between the duration of hypogonadism and BMT) in spine (r = -0.4; p = 0.003) and femoral region (r = -0.37; p = 0.013), the hypogonadal patients had a lower BMD in spine (p<0.005), but not in other regions analyzed. No correlation was found between duration of hypersomatotropism, GH/IGF-I levels and BMD. We conclude that the majority of patients with acromegaly have preserved BMD despite the presence of hypogonadism.
Palavra-chave acromegaly
bone mineral density
hypogonadism
osteoporosis
Idioma Inglês
Data de publicação 1997-01-01
Publicado em Osteoporosis International. Godalming: Springer-verlag London Ltd, v. 7, n. 3, p. 226-230, 1997.
ISSN 0937-941X (Sherpa/Romeo, fator de impacto)
Publicador Springer
Extensão 226-230
Fonte http://dx.doi.org/10.1007/BF01622293
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1997XD93400009
Endereço permanente http://repositorio.unifesp.br/handle/11600/25654

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