Quantitation of soluble E-receptor of T lymphocytes in serum from HIV-1 positive patients

Quantitation of soluble E-receptor of T lymphocytes in serum from HIV-1 positive patients

Autor Nunez, G. Google Scholar
Moura, N. C. Google Scholar
Hernandez, H. J. Google Scholar
Peixinho, Z. F. Google Scholar
Zeballos, R. S. Google Scholar
Cavalcante, N. Google Scholar
Flores, P. Google Scholar
Longo, I. M. Google Scholar
Mendes, N. F. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Human T lymphocytes carry a membrane receptor for sheep erythrocytes (E) related to the CD2 molecule. the E-receptor is found in a soluble form (Rs) in serum and can be quantitated by ''rocket electrophoresis'' using an anti-Rs serum obtained by immunizing sheep with autologous erythrocytes coated with Rs. Increased serum levels of Rs are found in patients with diseases associated with immunodepression. in the present study, 14 asymptomatic HIV-1 seropositive individuals were investigated regarding their Rs levels and delayed hypersensitivity skin tests every 3 months for a period of 35 months. All these patients progressed to AIDS in this period. Rs serum levels have also been quantitated in 14 normal individuals. the mean Rs values in normal individuals, asymptomatic, and AIDS patients were, respectively: 4.8 +/- 1.5 mm (SD), 9.6 +/- 1.9 mm (SD) and 11.3 +/- 2.4 mm (SD). An increase of Rs serum levels was observed when we compared normal individuals with CDC-II and CDC-IV clinical stage patients (P less-than 0.05, Mann-Whitney test) and CDC-II and CDC-IV patients, (P less-than 0.05, wilcoxon test). We have observed a depressed delayed hypersensitivity response to ubiquitous antigens in CDC-IV patients. Our results indicate that Rs serum levels can be used as a progression marker in HIV infected patients. J. Clin. Lab. Anal. 11:69-72.
Palavra-chave CD2
Idioma Inglês
Data de publicação 1997-01-01
Publicado em Journal of Clinical Laboratory Analysis. New York: Wiley-liss, v. 11, n. 1, p. 69-72, 1997.
ISSN 0887-8013 (Sherpa/Romeo, fator de impacto)
Publicador Wiley-Blackwell
Extensão 69-72
Fonte http://dx.doi.org/10.1002/(SICI)1098-2825(1997)11:1<69
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1997WF10500010
Endereço permanente http://repositorio.unifesp.br/handle/11600/25653

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