Effect of haloperidol on the development of the solid Ehrlich tumor in mice

Effect of haloperidol on the development of the solid Ehrlich tumor in mice

Author Kleeb, SR Google Scholar
Xavier, J. G. Google Scholar
Frussa, R. Google Scholar
Dagli, MLZ Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract We determined the effect of 13 days of treatment with 2.0 mg/kg haloperidol (s.c) on the development of the Ehrlich solid carcinoma, after inoculation of 1.5 x 10(6) Ehrlich ascites tumor cells into the left footpad of mice. the footpad thickness of haloperidol treated animals was significantly smaller than control from day two after tumor inoculation, to the end of the experiment. Histopathological examination showed that haloperidol treated mice apparently presented less necrotic areas within the tumor mass as well as less invasion of subepithelial connective tissue and other adjacent structures. in particular, in comparison with the control group, no nerve bundles were invaded by neoplastic cells in experimental mice. the possible mechanism underlying these results is discussed in light of the specific pharmacological properties of this neuroleptics drug.
Keywords haloperidol
Ehrlich adenocarcinoma
antitumor therapy
Language English
Date 1996-12-13
Published in Life Sciences. Oxford: Pergamon-Elsevier B.V., v. 60, n. 4-5, p. PL69-PL74, 1996.
ISSN 0024-3205 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent PL69-PL74
Origin http://dx.doi.org/10.1016/S0024-3205(96)00636-4
Access rights Closed access
Type Article
Web of Science ID WOS:A1996VZ47000013
URI http://repositorio.unifesp.br/handle/11600/25647

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account