Effect of haloperidol on the development of the solid Ehrlich tumor in mice

Effect of haloperidol on the development of the solid Ehrlich tumor in mice

Autor Kleeb, SR Google Scholar
Xavier, J. G. Google Scholar
Frussa, R. Google Scholar
Dagli, MLZ Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Resumo We determined the effect of 13 days of treatment with 2.0 mg/kg haloperidol (s.c) on the development of the Ehrlich solid carcinoma, after inoculation of 1.5 x 10(6) Ehrlich ascites tumor cells into the left footpad of mice. the footpad thickness of haloperidol treated animals was significantly smaller than control from day two after tumor inoculation, to the end of the experiment. Histopathological examination showed that haloperidol treated mice apparently presented less necrotic areas within the tumor mass as well as less invasion of subepithelial connective tissue and other adjacent structures. in particular, in comparison with the control group, no nerve bundles were invaded by neoplastic cells in experimental mice. the possible mechanism underlying these results is discussed in light of the specific pharmacological properties of this neuroleptics drug.
Palavra-chave haloperidol
Ehrlich adenocarcinoma
antitumor therapy
Idioma Inglês
Data de publicação 1996-12-13
Publicado em Life Sciences. Oxford: Pergamon-Elsevier B.V., v. 60, n. 4-5, p. PL69-PL74, 1996.
ISSN 0024-3205 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão PL69-PL74
Fonte http://dx.doi.org/10.1016/S0024-3205(96)00636-4
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1996VZ47000013
Endereço permanente http://repositorio.unifesp.br/handle/11600/25647

Exibir registro completo


Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções



Minha conta