Effects of ethanol on energy balance of rats and the inappropriateness of intraperitoneal injection

Effects of ethanol on energy balance of rats and the inappropriateness of intraperitoneal injection

Autor Luz, J. Google Scholar
Griggio, Mauro Antonio Autor UNIFESP Google Scholar
Plapler, H. Google Scholar
DeMeoBancher, M. Google Scholar
CarvalhoKosmiskas, J. V. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Energy balance of female rats that were either injected daily with ethanol or received the alcohol by gavage was determined and the results compared with saline animals. Food intake, feces elimination, and body weight were recorded daily. After a 20-day period of treatment the animals were sacrificed and the energy content of the carcasses and feces was determined by bomb calorimetry. the results indicated that ethanol-injected animals underwent an impairment in the energy balance, with losses in body weight and body energy. Also, there was a decrease in metabolizable energy intake. the results of a group of saline rats pair-fed to alcohol-injected rats showed that the impairment of the energy balance was not only a consequence of the decreased energy intake, because the ethanol-fed animals had an energy balance that was worse than the one of the pair-fed rats, even though both had eaten the same amount of food Nevertheless, when alcohol was given by gavage, no alteration in the energy balance parameters was detected. Macroscopic observation of the abdominal cavity showed adherences in the gut of the alcohol-injected animals. It is concluded that the ethanol by itself does not alter the energy balance; however, depending on the route of administration it could indirectly impair the energy balance. Copyright (C) 1996 Elsevier Science Inc.
Palavra-chave ethanol
energy balance
alcohol
Idioma Inglês
Data de publicação 1996-11-01
Publicado em Alcohol. Oxford: Pergamon-Elsevier B.V., v. 13, n. 6, p. 575-580, 1996.
ISSN 0741-8329 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 575-580
Fonte http://dx.doi.org/10.1016/S0741-8329(96)00070-5
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1996VV53800007
Endereço permanente http://repositorio.unifesp.br/handle/11600/25635

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