Monosialoganglioside attenuates the excitatory and behavioural sensitization effects of ethanol

Monosialoganglioside attenuates the excitatory and behavioural sensitization effects of ethanol

Autor Bellot, R. G. Google Scholar
Camarini, R. Google Scholar
Vital, MABF Google Scholar
PalermoNeto, J. Google Scholar
Leyton, V Google Scholar
Frussa, R. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
INST MED LEGAL
Resumo The effects of long-term monosialoganglioside G(M1) treatment on the acute excitatory effects of ethanol and behavioural sensitization to this effect were studied, using locomotion frequency of mice observed in an open field as an experimental parameter. G(M1) (30 mg/kg, once a day, for 21 days) did not modify mouse behaviour but decreased both the acute excitatory (1.8 g/kg) and the behavioural sensitization effects of ethanol (1.8 g/kg, once a day for 21 days, 30 min after G(M1) injections). G(M1) administered acutely 30 min or 24 h before ethanol did not modify the ethanol-induced increase in locomotion frequency. These results agree with previous reports in which ganglioside treatment modified both dopaminergic plasticity and other behavioural and biochemical effects of ethanol.
Palavra-chave monosialoganglioside
ethanol
sensitization
locomotor activity
Idioma Inglês
Data de publicação 1996-10-17
Publicado em European Journal of Pharmacology. Amsterdam: Elsevier B.V., v. 313, n. 3, p. 175-179, 1996.
ISSN 0014-2999 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 175-179
Fonte http://dx.doi.org/10.1016/0014-2999(96)00641-3
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1996VN47300002
Endereço permanente http://repositorio.unifesp.br/handle/11600/25634

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