Monoamines and their metabolites in cerebrospinal fluid and temporal cortex of epileptic patients

Monoamines and their metabolites in cerebrospinal fluid and temporal cortex of epileptic patients

Autor NaffahMazzacoratti, M. G. Google Scholar
Amado, D. Google Scholar
Cukiert, A. Google Scholar
Gronich, G. Google Scholar
Marino, R. Google Scholar
Calderazzo, L. Google Scholar
Cavalheiro, E. A. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The involvement of monoamines in the initiation or maintenance of epileptic phenomena has been extensively studied in cerebral tissues and in cerebrospinal fluid. the present work was undertaken to study monoamines and their metabolites in human spiking and non-spiking temporal cortex excised from patients with complex partial seizures unresponsive to available anticonvulsants. the same substances were also analyzed by HPLC-ED in cerebrospinal fluid obtained 24 h before the surgical procedure and compared with those from patients with chronic headache and normal neurological evaluation. the results show increased 5-HT, 5-HIAA and HVA levels in spiking compared with non-spiking cortex. Cerebrospinal fluid levels of 5-HIAA and HVA are concomitantly increased in epileptic compared with headache patients.
Palavra-chave monoamine
epilepsy
cortex
cerebrospinal fluid
Idioma Inglês
Data de publicação 1996-10-01
Publicado em Epilepsy Research. Amsterdam: Elsevier B.V., v. 25, n. 2, p. 133-137, 1996.
ISSN 0920-1211 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 133-137
Fonte http://dx.doi.org/10.1016/0920-1211(96)00030-7
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1996VH59600007
Endereço permanente http://repositorio.unifesp.br/handle/11600/25629

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