Disruption of light-induced c-Fos immunoreactivity in the suprachiasmatic nuclei of chronic epileptic rats

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dc.contributor.author Sanabria, ERG
dc.contributor.author Scorza, F. A.
dc.contributor.author Bortolotto, Z. A.
dc.contributor.author Calderazzo, L. S.
dc.contributor.author Cavalheiro, E. A.
dc.date.accessioned 2016-01-24T11:40:34Z
dc.date.available 2016-01-24T11:40:34Z
dc.date.issued 1996-09-27
dc.identifier http://dx.doi.org/10.1016/S0304-3940(96)13020-2
dc.identifier.citation Neuroscience Letters. Clare: Elsevier Sci Ireland Ltd, v. 216, n. 2, p. 105-108, 1996.
dc.identifier.issn 0304-3940
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/25625
dc.description.abstract Photic stimulation during specific day periods may induce Fos oncoprotein expression within the ventrolateral part of the suprachiasmatic nucleus (SCN) in the hypothalamus of rodents. This phenomenon appears to be a major molecular mechanism for environmental light/dark cycle entrainment of the mammalian circadian clock. Light-dependent synchronization of circadian rhythmicity may be disrupted in epilepsy, a chronic neurological disorder often associated with chronobiological features such as seizure periodicity and disruption of endogenous biological rhythms. the present work examined the light-induced Fos protein expression on the SCN in the pilocarpine model of chronic epilepsy. Fos-like immunoreactivity was significantly reduced in the SCN of chronic epileptic rats after photic stimulation during the subjective night. These results indicate an altered Fos protein expression in the SCN of chronic epileptic rats. the present findings reveal that pathological neural events underlying epileptogenesis may disturb circadian rhythm regulation. the experimental study of circadian clock activity in the SCN may clarify the molecular bases of chronobiological disturbances in epilepsy. en
dc.format.extent 105-108
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Neuroscience Letters
dc.rights Acesso restrito
dc.subject hypothalamus en
dc.subject circadian rhythm en
dc.subject biological clock en
dc.subject epilepsy en
dc.subject pilocarpine en
dc.subject immediate early genes en
dc.title Disruption of light-induced c-Fos immunoreactivity in the suprachiasmatic nuclei of chronic epileptic rats en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo,ESCOLA PAULISTA MED,LAB NEUROL EXPT,BR-04023900 São Paulo,BRAZIL
dc.description.affiliationUnifesp Universidade Federal de São Paulo,ESCOLA PAULISTA MED,LAB NEUROL EXPT,BR-04023900 São Paulo,BRAZIL
dc.identifier.doi 10.1016/S0304-3940(96)13020-2
dc.description.source Web of Science
dc.identifier.wos WOS:A1996VL52400009



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