Disruption of light-induced c-Fos immunoreactivity in the suprachiasmatic nuclei of chronic epileptic rats

Disruption of light-induced c-Fos immunoreactivity in the suprachiasmatic nuclei of chronic epileptic rats

Author Sanabria, ERG Google Scholar
Scorza, F. A. Google Scholar
Bortolotto, Z. A. Google Scholar
Calderazzo, L. S. Google Scholar
Cavalheiro, E. A. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Photic stimulation during specific day periods may induce Fos oncoprotein expression within the ventrolateral part of the suprachiasmatic nucleus (SCN) in the hypothalamus of rodents. This phenomenon appears to be a major molecular mechanism for environmental light/dark cycle entrainment of the mammalian circadian clock. Light-dependent synchronization of circadian rhythmicity may be disrupted in epilepsy, a chronic neurological disorder often associated with chronobiological features such as seizure periodicity and disruption of endogenous biological rhythms. the present work examined the light-induced Fos protein expression on the SCN in the pilocarpine model of chronic epilepsy. Fos-like immunoreactivity was significantly reduced in the SCN of chronic epileptic rats after photic stimulation during the subjective night. These results indicate an altered Fos protein expression in the SCN of chronic epileptic rats. the present findings reveal that pathological neural events underlying epileptogenesis may disturb circadian rhythm regulation. the experimental study of circadian clock activity in the SCN may clarify the molecular bases of chronobiological disturbances in epilepsy.
Keywords hypothalamus
circadian rhythm
biological clock
epilepsy
pilocarpine
immediate early genes
Language English
Date 1996-09-27
Published in Neuroscience Letters. Clare: Elsevier Sci Ireland Ltd, v. 216, n. 2, p. 105-108, 1996.
ISSN 0304-3940 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 105-108
Origin http://dx.doi.org/10.1016/S0304-3940(96)13020-2
Access rights Closed access
Type Article
Web of Science ID WOS:A1996VL52400009
URI http://repositorio.unifesp.br/handle/11600/25625

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