Morphological action of tamoxifen in the endometrium of persistent estrous rats

Morphological action of tamoxifen in the endometrium of persistent estrous rats

Autor Patriarca, M. T. Google Scholar
Simoes, R. D. Google Scholar
Smaniotto, S. Google Scholar
DeTeves, D. C. Google Scholar
Simoes, M. J. Google Scholar
EvencioNeto, J. Google Scholar
DeFreitas, V Google Scholar
DeLima, G. R. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Background. the aim of this study was to evaluate the action of tamoxifen on the endometrium in stales of chronic anovulation.Methods. Thirty-eight rats inducted to persistent estrous (testosterone propionate) confirmed by hormonal colpocytology were divided into a control and an experimental group; the latter received tamoxifen and had fragments of the uterine horns processed for morphological and morphometrical analysis. Data were analysed statistically by the Mann-Whitney and Student's t tests.Results. Our findings revealed minor uterine weight, epithelial thickness; number of endometrial glands and low eosinophil counts in the group that received tamoxifen. These results were statistically significant. We often observed areas of metaplasic stratified squamous epithelium between cylindrical epithelial cells in both groups.Conclusions. Our results indicate that antiestrogenic effect of tamoxifen was only partial in persistent estrous, since there was no blocking against the squamous metaplasia of the endometrium.
Palavra-chave endometrium
persistent estrous
tamoxifen
uterus
Idioma Inglês
Data de publicação 1996-09-01
Publicado em Acta Obstetricia Et Gynecologica Scandinavica. Copenhagen: Munksgaard Int Publ Ltd, v. 75, n. 8, p. 707-710, 1996.
ISSN 0001-6349 (Sherpa/Romeo, fator de impacto)
Publicador Munksgaard Int Publ Ltd
Extensão 707-710
Fonte http://dx.doi.org/10.3109/00016349609065731
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1996VP50200004
Endereço permanente http://repositorio.unifesp.br/handle/11600/25624

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