Functional properties of agmatine in rat vas deferens

Functional properties of agmatine in rat vas deferens

Autor Jurkiewicz, N. H. Google Scholar
doCarmo, L. G. Google Scholar
Hirata, H. Google Scholar
Santos, W. D. Google Scholar
Jurkiewicz, A. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Experiments were performed with rat vas deferens to verify whether agmatine, an endogenous ligand for adrenoceptors and imidazoline receptors, can influence sympathetic neurotransmission, with respect to contractions induced by transmural nerve stimulation, contractions induced by exogenous noradrenaline, and overflow of endogenous noradrenaline. It was shown that agmatine (a) caused a dose-dependent potentiation of electrically induced twitches, up to about 70% in relation to controls, (b) shifted to the right the inhibitory concentration-response curves for clonidine on electrically induced twitches, indicating competitive antagonism at presynaptic ol-adrenoceptors, with a pA(2) value of 4.12 +/- 0.10, (c) shifted to the right the concentration-response curves for noradrenaline-induced contractions, indicating competitive antagonism at postsynaptic alpha-adrenoceptors as well, with a pA(2) value of 4.03 +/- 0.10, and (d) caused a dose-dependent increase of KCl-induced overflow of noradrenaline, up to about 90% in relation to controls. It is concluded that agmatine has multiple effects on sympathetic neurotransmission in rat vas deferens.
Palavra-chave vas deferens
noradrenaline
agmatine
neurotransmission
imidazoline receptor
adrenoceptor
Idioma Inglês
Data de publicação 1996-07-04
Publicado em European Journal of Pharmacology. Amsterdam: Elsevier B.V., v. 307, n. 3, p. 299-304, 1996.
ISSN 0014-2999 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 299-304
Fonte http://dx.doi.org/10.1016/0014-2999(96)00274-9
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1996UY10800007
Endereço permanente http://repositorio.unifesp.br/handle/11600/25615

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