Tumor necrosis factor alpha (TNF-alpha) and sepsis: Evidence for a role in host defense

Tumor necrosis factor alpha (TNF-alpha) and sepsis: Evidence for a role in host defense

Autor Rigato, O. Google Scholar
Ujvari, S. Google Scholar
Castelo, A. Google Scholar
Salomão, Reinaldo Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Serum levels of TNF-alpha were evaluated in 29 patients with sepsis, using TNF-alpha sensitive L929 cells (sensitivity=15 pg/ml), Blood samples were collected serially at the first 24-36 h of symptoms. Seventeen patients had severe underlying disease and 12 patients had mild or no underlying disease, Shock was present in 25 patients, Overall mortality was 62.1%, TNF-alpha was detected in nine patients (range: 57.7-3,169 pg/ml), There was a tendency to detect TNF-alpha in patients with mild or no underlying disease (p=0.07). Detection of TNF-alpha was associated with survival (p=0.0003) even when adjusted for severity of underlying disease (p=0.005), shock (p=0.0005), coagulation abnormality (p=0.002) and immunosuppressive therapy (p=0.005), using a bivariate analysis. in this investigation, detection of circulating TNF-alpha was predictive of good outcome in septic patients, suggesting a role for this cytokine in host-defense against this kind of infection.
Idioma Inglês
Data de publicação 1996-07-01
Publicado em Infection. Munich 80: Mmw Medizin Verlag Gmbh, v. 24, n. 4, p. 314-318, 1996.
ISSN 0300-8126 (Sherpa/Romeo, fator de impacto)
Publicador Mmw Medizin Verlag Gmbh
Extensão 314-318
Fonte http://dx.doi.org/10.1007/BF01743367
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1996VD19800006
Endereço permanente http://repositorio.unifesp.br/handle/11600/25611

Exibir registro completo




Arquivo

Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta