Use of the in vitro induced antibody production test (IVIAP) to elucidate inconclusive status of HIV-1 infection

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dc.contributor.author Bellei, N.
dc.contributor.author Granato, C.
dc.contributor.author Tomiyama, H.
dc.date.accessioned 2016-01-24T11:40:32Z
dc.date.available 2016-01-24T11:40:32Z
dc.date.issued 1996-06-01
dc.identifier http://dx.doi.org/10.1016/S0732-8893(96)00119-8
dc.identifier.citation Diagnostic Microbiology and Infectious Disease. New York: Elsevier B.V., v. 25, n. 2, p. 65-69, 1996.
dc.identifier.issn 0732-8893
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/25603
dc.description.abstract Studies have demonstrated the diagnostic usefulness of in vitro production of virus-specific antibodies by peripheral blood mononuclear cells (PMBC) from HN-infected subjects. We evaluated the IVIAP (in vitro induced antibody production) by lympocytes from peripheral blood of 30 adult patients. Samples included 10 patients with inconclusive status of HIV-1 infection on previous serologic screening (2 blood donors, 8 with high risk behavior), 10 AIDS patients (CDC II-IV), and 10 known seronegative subjects. Positive IVIAP results were obtained on 2 of 10 inconclusive cases, earlier than seroconversion would demonstrate. the 8 remaining cases resulted in a negative outcome on IVIAP test, evert in 2 seronegative homosexuals presenting Kaposi's sarcoma. Results showed 100% concordance either with a clinical/serological follow-up done after IVIAP tests or PCR performed for Kaposi's cases. Also, no false-positive or false negative was detected on control groups. We concluded that IVIAP could identify the real status of HIV infection in a shorter time and with low cost compared to conventional serological methods currently available. the IVIAP test is easily performed so that can be considered as a routine supplemental test. en
dc.format.extent 65-69
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Diagnostic Microbiology and Infectious Disease
dc.rights Acesso restrito
dc.title Use of the in vitro induced antibody production test (IVIAP) to elucidate inconclusive status of HIV-1 infection en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation FED UNIV São Paulo,ESCOLA PAULISTA MED,VIROL LAB,São Paulo,BRAZIL
dc.description.affiliationUnifesp FED UNIV São Paulo,ESCOLA PAULISTA MED,VIROL LAB,São Paulo,BRAZIL
dc.identifier.doi 10.1016/S0732-8893(96)00119-8
dc.description.source Web of Science
dc.identifier.wos WOS:A1996VG63700002



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