Transcriptional regulatory elements in the rat bradykinin B-2 receptor gene

Transcriptional regulatory elements in the rat bradykinin B-2 receptor gene

Autor Pesquero, J. B. Google Scholar
Lindsey, C. J. Google Scholar
Paiva, ACM Google Scholar
Ganten, D. Google Scholar
Bader, M. Google Scholar
Instituição MAX DELBRUCK CTR MOLEC MED
Universidade Federal de São Paulo (UNIFESP)
Resumo In an attempt to elucidate the mechanisms underlying the regulation of bradykinin B2 receptor gene expression, the molecular structure of the rat gene including the 5'-flanking region was characterized (J. Biol. Chem. 269: 26920-26925, 1994). in this study we show that the gene spans about 32 kb, including a long first intron of 25 kb. the promoter region drives reporter gene expression in NG108-15 neuroglioma cells, and its expression is upregulated by cAMP bradykinin, phorbol esters and by coexpression of an activated ras oncogene but not by dexamethasone.
Palavra-chave bradykinin
receptor
gene
promoter
cAMP
ras oncogene
Idioma Inglês
Data de publicação 1996-06-01
Publicado em Immunopharmacology. Amsterdam: Elsevier B.V., v. 33, n. 1-3, p. 36-41, 1996.
ISSN 0162-3109 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 36-41
Fonte http://dx.doi.org/10.1016/0162-3109(96)00080-X
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1996VA29800006
Endereço permanente http://repositorio.unifesp.br/handle/11600/25601

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