A systematic evaluation of linkage studies in bipolar disorder

A systematic evaluation of linkage studies in bipolar disorder

Autor Turecki, G. Google Scholar
Rouleau, G. A. Google Scholar
Mari, J. J. Google Scholar
Morgan, K. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Genetic factors have long been implicated in the aetiology of bipolar disorder (ED). During the past two decades several linkage studies have been carried out with the aim of identifying major genes. However, remarkable discrepancies in results both between and within studies have constituted a major problem. in order to elucidate some of these conflicts, we assessed the published literature on linkage studies of bipolar disorder, focusing on methodological issues. Studies published between January 1980 and December 1994 were identified by computerized literature searches and subsequent scanning of review articles, and the reference lists of the articles primarily identified. A set of defined inclusion and exclusion criteria was used to select studies for assessment. A total of 31 variables were determined, and pre-defined codes were assigned in a structured manner. More than 200 citations were reviewed, and 60 articles were included in this study. Descriptive statistical analyses of the variables, as well as associations between variables, are presented. the findings are discussed with regard to the possibility that, beyond the genetic complexity of the disorder itself, there are several other similarly complicated study design issues which should be more carefully observed. Moreover, the need for standardization of basic criteria to use and report clinical and analytical parameters employed in linkage studies is strongly suggested.
Palavra-chave manic-depressive illness
bipolar disorder
linkage analysis
Idioma Inglês
Data de publicação 1996-05-01
Publicado em Acta Psychiatrica Scandinavica. Copenhagen: Munksgaard Int Publ Ltd, v. 93, n. 5, p. 317-326, 1996.
ISSN 0001-690X (Sherpa/Romeo, fator de impacto)
Publicador Munksgaard Int Publ Ltd
Extensão 317-326
Fonte http://dx.doi.org/10.1111/j.1600-0447.1996.tb10655.x
Direito de acesso Acesso restrito
Tipo Resenha
Web of Science WOS:A1996UP98900001
Endereço permanente http://repositorio.unifesp.br/handle/11600/25591

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