Na+K+ ATPase activity in the rat hippocampus: A study in the pilocarpine model of epilepsy

Na+K+ ATPase activity in the rat hippocampus: A study in the pilocarpine model of epilepsy

Author Fernandes, MJS Google Scholar
NaffahMazzacoratti, M. G. Google Scholar
Cavalheiro, E. A. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Biochemical abnormalities have been implicated in possible mechanisms underlying the epileptic phenomena. Some of these alterations include changes in the activity of several enzymes present in epileptic tissues. Systemic administration of pilocarpine in rats induces electrographic and behavioral limbic seizures and status epilepticus, that is followed by a transient seizure-free period (silent period). Finally a chronic phase ensues, characterized by spontaneous and recurrent seizures (chronic period), that last for the rest of the animal's life. the present work aimed to study the activity of the enzyme Na+ K+ ATPase, in rat hippocampus, during the three phases of this epilepsy model. the enzyme activity was determined at different time points from pilocarpine administration (1 and 24 h of status epilepticus. during the silent and chronic period) using a spectrophotometric assay previously described by Mishra and Delivoria-Papadopoulos [Neurochem. Res. (1988) 13, 765-770]. the results showed decreased enzyme activities during the acute and silent periods and increased Na+ K+ ATPase activity during the chronic phase. These data show that changes in Na+ K+ ATPase activity could be involved in the appearance of spontaneous and recurrent seizures following brain damage induced by pilocarpine injection. Copyright (C) 1996 Elsevier B.V.
Language English
Date 1996-05-01
Published in Neurochemistry International. Oxford: Pergamon-Elsevier B.V., v. 28, n. 5-6, p. 497-500, 1996.
ISSN 0197-0186 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 497-500
Access rights Closed access
Type Article
Web of Science ID WOS:A1996UQ60400004

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