Plasma kallikrein and tissue-type plasminogen activator compete for a common pathway into the liver

Plasma kallikrein and tissue-type plasminogen activator compete for a common pathway into the liver

Autor Nagaoka, M. R. Google Scholar
Kouyoumdjian, M. Google Scholar
Borges, D. R. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The liver is the main organ used to clear both tissue and plasma kallikreins from the circulation. Rat plasma kallikrein (rPK) is internalized by hepatocytes by a receptor-mediated mechanism. Since plasma kallikrein and tissue-type plasminogen activator (tPA) are both important for fibrinolysis, we now compare characteristics of the clearance of both by the isolated, exsanguinated and perfused rat liver. in preliminary experiments we observed, in vitro, that rPK and tPA neither form a complex with, nor are they substrates for, each other. the characteristics of rPK and tPA clearance are similar, and we observed that 20 and 200 molar excess of tPA in the perfusion medium decreased and abolished the rPK liver clearance, respectively. These results suggest that rPK and tPA share a common pathway for liver clearance.
Palavra-chave plasma kallikrein
tissue-type plasminogen activator
liver receptor
liver
Idioma Inglês
Data de publicação 1996-05-01
Publicado em Immunopharmacology. Amsterdam: Elsevier B.V., v. 32, n. 1-3, p. 88-90, 1996.
ISSN 0162-3109 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 88-90
Fonte http://dx.doi.org/10.1016/0162-3109(96)88182-3
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1996UR64300021
Endereço permanente http://repositorio.unifesp.br/handle/11600/25588

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