Lack of Fos-like immunoreactivity after spontaneous seizures or reinduction of status epilepticus by pilocarpine in rats

Lack of Fos-like immunoreactivity after spontaneous seizures or reinduction of status epilepticus by pilocarpine in rats

Autor Mello, LEAM Google Scholar
Kohman, C. M. Google Scholar
Tan, A. M. Google Scholar
Cavalheiro, E. A. Google Scholar
Finch, D. M. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
UNIV CALIF LOS ANGELES
Resumo Acute seizures and status epilepticus induced by pilocarpine lead to the expression of Fos-like immunoreactivity in several specific brain areas in a manner similar to that of other models of limbic seizures. Upon development of status epilepticus after systemic pilocarpine injection, animals develop a state where chronic spontaneous seizures recur. Assessment of Fos-like immunoreactivity after such spontaneous seizures or after status epilepticus reinduction reveals either lack of staining or a weak reaction in a few brain areas including the ventral tip of the dentate gyrus, prepiriform, lateral piriform and perirhinal cortices, and scattered locations throughout temporal neocortex. Our results suggest that status epiiepticus induction may lead to a long-lasting state of Fos down-regulation.
Palavra-chave epilepsy
neuronal plasticity
epileptogenesis
temporal lobe
hippocampus
entorhinal cortex
prepiriform cortex
pilocarpine
Idioma Inglês
Data de publicação 1996-04-19
Publicado em Neuroscience Letters. Clare: Elsevier Sci Ireland Ltd, v. 208, n. 2, p. 133-137, 1996.
ISSN 0304-3940 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 133-137
Fonte http://dx.doi.org/10.1016/0304-3940(96)12562-3
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1996UH10800016
Endereço permanente http://repositorio.unifesp.br/handle/11600/25580

Exibir registro completo




Arquivo

Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta