Morphological and biochemical action of dipyrone on rat placenta

Morphological and biochemical action of dipyrone on rat placenta

Autor Espiridião, Silvia Autor UNIFESP Google Scholar
Oliveira, R. M. Google Scholar
Doine, A. Google Scholar
Simoes, M. J. Google Scholar
Focchi, GRA Google Scholar
Neto, J. E. Google Scholar
Kopelman, B. I. Google Scholar
Kulay Júnior, Luiz Autor UNIFESP Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Resumo 1. the morphological and biochemical action of dipyrone (N-[2,3-dimethyl-5-oxo-1-phenyl-3-pyrazolin-4-yl] methylamino methanesulfonate, sodium monohydrate) on the placenta of albino rats was studied by means of karyometry of trophoblastic giant cells and by determinations of DNA, RNA and total protein contents.2. the animals were treated with a single daily dose of 50 mg/kg body weight during 5 different periods: from the 9th to the 12th, 11th to the 14th, 13th to the 16th, 15th to the 18th or 17th to the 20th day of pregnancy,3. Karyometric results showed that the nuclear volumes of placental cells in rats treated with dipyrone during the first 3 periods were significantly greater than in control animals and that, closer to term, no differences were observed in this regard. Only the animals treated from the 9th to the 12th day of pregnancy had higher placental contents of DNA, RNA and protein than the corresponding controls.4. Our results showed that dipyrone had a blocking effect on placental cell division which occurs mainly in the initial steps of placental development.
Assunto rat
placenta
pregnancy
dipyrone
aminopyrine
DNA
Idioma Inglês
Data 1996-04-01
Publicado em General Pharmacology. Oxford: Pergamon-Elsevier B.V., v. 27, n. 3, p. 505-507, 1996.
ISSN 0306-3623 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 505-507
Fonte http://dx.doi.org/10.1016/0306-3623(95)02066-7
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1996UJ44600017
URI http://repositorio.unifesp.br/handle/11600/25576

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