Effects of microgram doses of haloperidol on open-field behavior in mice

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dc.contributor.author Conceição, Isaltino Marcelo da [UNIFESP]
dc.contributor.author Frussa, R.
dc.date.accessioned 2016-01-24T11:40:30Z
dc.date.available 2016-01-24T11:40:30Z
dc.date.issued 1996-04-01
dc.identifier http://dx.doi.org/10.1016/0091-3057(95)02085-3
dc.identifier.citation Pharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 53, n. 4, p. 833-838, 1996.
dc.identifier.issn 0091-3057
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/25574
dc.description.abstract This study was designed to evaluate the effects of low doses of haloperidol on the open-field behavior of mice. A three-phase effect of haloperidol on the motor activity of mice was observed (depression, no effect, depression). This three-phase action was clear-cut in three experimental approaches (amphetamine-induced hyperactivity, and apomorphine- and bromocriptine-induced hypoactivity). A differential action of haloperidol on dopamine receptors mediating motor stimulation and motor depression was proposed. the present data indicate that considerably more attention should be paid to the novel behavioral and biochemical actions of neuroleptic drugs in the microgram dose range. en
dc.format.extent 833-838
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Pharmacology Biochemistry and Behavior
dc.rights Acesso restrito
dc.subject haloperidol en
dc.subject amphetamine en
dc.subject apomorphine en
dc.subject bromocriptine en
dc.subject open-field test en
dc.title Effects of microgram doses of haloperidol on open-field behavior in mice en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation ESCOLA PAULISTA MED,DEPT FARMACOL,BR-04034 São Paulo,BRAZIL
dc.description.affiliationUnifesp ESCOLA PAULISTA MED,DEPT FARMACOL,BR-04034 São Paulo,BRAZIL
dc.identifier.doi 10.1016/0091-3057(95)02085-3
dc.description.source Web of Science
dc.identifier.wos WOS:A1996UC05500011



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