Effects of microgram doses of haloperidol on open-field behavior in mice

Effects of microgram doses of haloperidol on open-field behavior in mice

Author Conceição, Isaltino Marcelo da Autor UNIFESP Google Scholar
Frussa, R. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract This study was designed to evaluate the effects of low doses of haloperidol on the open-field behavior of mice. A three-phase effect of haloperidol on the motor activity of mice was observed (depression, no effect, depression). This three-phase action was clear-cut in three experimental approaches (amphetamine-induced hyperactivity, and apomorphine- and bromocriptine-induced hypoactivity). A differential action of haloperidol on dopamine receptors mediating motor stimulation and motor depression was proposed. the present data indicate that considerably more attention should be paid to the novel behavioral and biochemical actions of neuroleptic drugs in the microgram dose range.
Keywords haloperidol
amphetamine
apomorphine
bromocriptine
open-field test
Language English
Date 1996-04-01
Published in Pharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 53, n. 4, p. 833-838, 1996.
ISSN 0091-3057 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 833-838
Origin http://dx.doi.org/10.1016/0091-3057(95)02085-3
Access rights Closed access
Type Article
Web of Science ID WOS:A1996UC05500011
URI http://repositorio.unifesp.br/handle/11600/25574

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