Effects of microgram doses of haloperidol on open-field behavior in mice

Effects of microgram doses of haloperidol on open-field behavior in mice

Autor Conceição, Isaltino Marcelo da Autor UNIFESP Google Scholar
Frussa, R. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo This study was designed to evaluate the effects of low doses of haloperidol on the open-field behavior of mice. A three-phase effect of haloperidol on the motor activity of mice was observed (depression, no effect, depression). This three-phase action was clear-cut in three experimental approaches (amphetamine-induced hyperactivity, and apomorphine- and bromocriptine-induced hypoactivity). A differential action of haloperidol on dopamine receptors mediating motor stimulation and motor depression was proposed. the present data indicate that considerably more attention should be paid to the novel behavioral and biochemical actions of neuroleptic drugs in the microgram dose range.
Palavra-chave haloperidol
amphetamine
apomorphine
bromocriptine
open-field test
Idioma Inglês
Data de publicação 1996-04-01
Publicado em Pharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 53, n. 4, p. 833-838, 1996.
ISSN 0091-3057 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 833-838
Fonte http://dx.doi.org/10.1016/0091-3057(95)02085-3
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1996UC05500011
Endereço permanente http://repositorio.unifesp.br/handle/11600/25574

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