Role of thyroid hormone in protecting against gentamicin-induced nephrotoxicity

Role of thyroid hormone in protecting against gentamicin-induced nephrotoxicity

Author Gomes, Guiomar Nascimento Google Scholar
Silva, Vera Lidia Costa Autor UNIFESP Google Scholar
Cavanal, Maria de Fátima Autor UNIFESP Google Scholar
Gil, Frida Zaladek Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de São Carlos (UFSCar)
Abstract This study investigates the protective effect of thyroid hormone (T-4) in an in vivo model of gentamicin nephrotoxicity, Rats were divided into a control group and groups treated with either T-4 alone (C + T-4), gentamicin 40 mg/kg/d alone (G(40)), or T-4 for 14 days with G(40) in the last 10 days (T-4 + G(40)). the glomerular variables assessed showed similar results in groups G(40) and T-4 + G(40), (glomerular filtration rate, 5.31 +/- 0.27 mL . min(-1) . kg(-1) with G(40) and 5.40 +/- 0.23 mL . min(-1) . kg(-1) with T-4 + G(40); renal plasma flow, 14.87 +/- 0.97 mL . min(-1) . kg(-1) with G(40) and 14.71 +/- 0.97 mL . min(-1) . kg(-1) with T-4 + G(40). Some values of tubular functions that were impaired in the group that received gentamicin alone were similar to the values in the group treated with T-4 + G(40). Urine HCO3- concentration was 1.98 +/- 0.44 mEq/mL/kg with G(40), 0.85 +/- 0.26 mEq/mL/kg with T-4 + G(40), 0.879 +/- 0.117 mEq/mL/kg with C + T-4, and 0.882 +/- 0.06 mEq/mL/kg in the control group; net acid excretion was 4.01 +/- 0.11 mu Eq . min(-1) . kg(-1) with G(40), 5.24 +/- 0.34 mu Eq min(-1) . kg(-1) with T-4 + G(40), 5.47 +/- 0.24 mu Eq . min(-1) . kg(-1) with C + T-4, and 5.86 +/- 0.29 mu Eq . min(-1) . kg(-1) in the control group; and sodium excretion was 10.32 +/- 1.09 mu Eq . min(-1) . kg(-1) with G(40), 4.72 +/- 0.43 mu Eq . min(-1) . kg(-1) with T-4 + G(40), 4.84 +/- 0.20 mu Eq . min(-1) . kg(-1) for C + T-4, and 7.12 +/- 0.86 mu Eq . min(-1) . kg(-1) in the control group. These results suggest that T-4 protects the tubular function against epithelial injury but does not prevent the glomerular changes induced by gentamicin.
Language English
Date 1996-04-01
Published in Current Therapeutic Research-clinical and Experimental. New York: Excerpta Medica Inc, v. 57, n. 4, p. 278-287, 1996.
ISSN 0011-393X (Sherpa/Romeo, impact factor)
Publisher Excerpta Medica Inc
Extent 278-287
Origin http://dx.doi.org/10.1016/S0011-393X(96)80035-X
Access rights Open access Open Access
Type Article
Web of Science ID WOS:A1996UF83900004
URI http://repositorio.unifesp.br/handle/11600/25572

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