Comparative bioavailability study of an once-a-week matrix versus a twice-a-week reservoir transdermal estradiol delivery systems in postmenopausal women

Comparative bioavailability study of an once-a-week matrix versus a twice-a-week reservoir transdermal estradiol delivery systems in postmenopausal women

Autor Baracat, Edmundo Autor UNIFESP Google Scholar
|Haidar, Mauro Autor UNIFESP Google Scholar
Castelo, Adauto Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Lima, Geraldo Rodrigues de Autor UNIFESP Google Scholar
Vieira, Jose Gilberto Henrique Autor UNIFESP Google Scholar
Peloso, U. Google Scholar
Casoy, J. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
WYETH BRAZIL
WYETH AYERST INT
Resumo An open-label, randomised, crossover study was conducted with in healthy postmenopausal women to compare the relative bioavailability of a matrix transdermal estradiol delivery system worn for 7 consecutive days, versus a reservoir transdermal patch worn for 4 days followed by its immediate replacement by another patch worn for further 3 consecutive days. There was a minimum 7-day washout period between the two study periods. Both systems were labelled to release approximately 50 mu g/day of estradiol. Twenty-six subjects were evaluated with regard to estradiol serum levels. Blood samples were taken immediately before and at regular intervals until 192 h after the initiation of each study treatment (patch application) and assayed for estradiol. There was no difference between the patches with regard to C-max. Based on the relative bioavailability, one matrix patch proved to be bioequivalent to two reservoir patches worn consecutively for 7 days. These results demonstrate the ability of one matrix patch to deliver consistent therapeutic levels of estradiol over a 7-day period.
Palavra-chave estrogen replacement therapy
postmenopause
estradiol
bioavailability
transdermal
Idioma Inglês
Data de publicação 1996-04-01
Publicado em Maturitas. Clare: Elsevier Sci Ireland Ltd, v. 23, n. 3, p. 285-291, 1996.
ISSN 0378-5122 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 285-291
Fonte http://dx.doi.org/10.1016/0378-5122(95)00987-6
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:A1996UQ91700005
Endereço permanente http://repositorio.unifesp.br/handle/11600/25571

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