Histomorphometry of the postmenopausal endometrium after oral and transdermal estrogen replacement therapy

Histomorphometry of the postmenopausal endometrium after oral and transdermal estrogen replacement therapy

Autor Baracat, E. C. Google Scholar
Simoes, MDJ Google Scholar
Haidar, Mauro Abi Autor UNIFESP Google Scholar
Neto, J. E. Google Scholar
Novo, N. F. Google Scholar
DeLima, G. R. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo We studied the morphological and morphometrical aspects of the endometrium of postmenopausal women treated with oral conjugated estrogens and transdermal 17 beta-estradiol for 28 days. Light microscopy revealed that the endometrial glandular epithelium and stroma were more responsive to stimulation than the surface epithelium. Proliferative changes were more intense in the groups that received 1.25 mg/day of conjugated estrogens and 50 mu g/day of transdermal 17 beta-estradiol in comparison with the group that received 0.625 mg/day of conjugated estrogens. Morphometry indicated that the endometrial gland/stroma ratio was higher in the groups that received 1.25 mg/day of conjugated estrogens and 50 mu g/day of transdermal 17 beta-estradiol, an effect that was significantly greater than that observed in women receiving 0.625 mg/day of conjugated estrogens.
Assunto postmenopausal endometrium
morphometry
estrogen replacement therapy
Idioma Inglês
Data 1996-03-01
Publicado em Menopause-the Journal of the North American Menopause Society. Philadelphia: Lippincott-raven Publ, v. 3, n. 1, p. 44-50, 1996.
ISSN 1072-3714 (Sherpa/Romeo, fator de impacto)
Editor Lippincott-raven Publ
Extensão 44-50
Fonte http://dx.doi.org/10.1097/00042192-199603010-00009
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1996UC29000009
URI http://repositorio.unifesp.br/handle/11600/25567

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