Sensitivity of the Bothrops jararaca snake uterus to oxytocin and acetylcholine

Sensitivity of the Bothrops jararaca snake uterus to oxytocin and acetylcholine

Autor Abdalla, FMF Google Scholar
Hayashi, H. Google Scholar
Picarelli, Z. P. Google Scholar
Porto, C. S. Google Scholar
Abreu, L. C. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
INST BUTANTAN
Resumo The influence of hormones on the uterine smooth muscle sensitivity has been demonstrated in mammals; however in nonmammalian species much remains to be clarified. This study investigated the sensitivity of the snake (Bothrops jararaca) uterus to oxytocin and acetylcholine. the snakes were divided into three experimental groups: snakes with uterine segments weighing less than or equal to 20.00 mg (A), snakes with uterine segments weighing between 20.01 and 35.00 mg (B) and snakes with uterine segments weighing greater than or equal to 35.01 mg (C). the histomorphometric analysis of the uterus showed an increase in the smooth muscle layer thickness in groups B and C, when compared with group A, suggesting different hormonal conditions of the animals. Cumulative concentration-effect curves to oxytocin and acetylcholine were obtained in uteri of the three experimental groups and the pD(2) values determined. the sensitivity of the snake uterus to oxytocin increased in groups B and C (concentration-effect curves shifted to the left and pD(2) values increased) when compared with group A. the concentration effect curves to acetylcholine were biphasic and shifted to the left, suggesting two binding sites (low and high affinity binding sites) in snake uteri of groups B and C. These results suggest that sex steroids may modulate the sensitivity of the snake uterus to oxytocin and acetylcholine.
Palavra-chave snake uterus
oxytocin
acetylcholine
Idioma Inglês
Data de publicação 1996-03-01
Publicado em Comparative Biochemistry and Physiology C-pharmacology Toxicology & Endocrinology. Oxford: Pergamon-Elsevier B.V., v. 113, n. 3, p. 353-358, 1996.
ISSN 0742-8413 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 353-358
Fonte http://dx.doi.org/10.1016/0742-8413(95)02065-9
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1996UU66100006
Endereço permanente http://repositorio.unifesp.br/handle/11600/25563

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