Conditioned immunosuppression in orally immunized mice

Conditioned immunosuppression in orally immunized mice

Autor Morato, E. F. Google Scholar
GerbaseDelima, M. Google Scholar
Gorczynski, R. M. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
UNIV TORONTO
Resumo Mice were given oral immunization after pretreatment with a regimen (cyclophosphamide and a novel taste in the drinking water, chocolate milk (CHM)) which leads to suppression of the antibody response to intravenously administered antigens given concurrently with CHM. Following this treatment mice were reexposed to CHM and IgM and IgA antibody forming cells (AFC) were measured in spleen and Peyer's patch cells. Conditioned immunosuppression of AFC production was most marked (>fivefold) for IgA-AFC in Peyer's patch, with effects of lesser magnitude for IgM-AFC in Peyer's patch (twofold) and both IgM- and IgA-AFC in spleen. Analysis of cytokine production from stimulated Peyer's patch and splenic T cells in vitro showed significant decreased production of both IL-2 and IL-4, with the latter being the predominant cytokine produced in Pryer's patch cells of control animals. (C) 1996 Academic Press, Inc.
Idioma Inglês
Data 1996-03-01
Publicado em Brain Behavior and Immunity. San Diego: Academic Press Inc Jnl-comp Subscriptions, v. 10, n. 1, p. 44-54, 1996.
ISSN 0889-1591 (Sherpa/Romeo, fator de impacto)
Editor Academic Press Inc Jnl-comp Subscriptions
Extensão 44-54
Fonte http://dx.doi.org/10.1006/brbi.1996.0004
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1996UK78600004
URI http://repositorio.unifesp.br/handle/11600/25560

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